Candidate gene studies in hypodontia suggest role for FGF3

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dc.contributor.authorVieira, Alexandre Rezende
dc.contributor.authorD'Souza, Rena
dc.contributor.authorMues, Gabriele
dc.contributor.authorDeeley, Kathleen
dc.contributor.authorHsin, Hongyuan
dc.contributor.authorKüchler, Erika Calvano
dc.contributor.authorMeira, Raquel
dc.contributor.authorPatır, Aslı
dc.contributor.authorTannure, Patrícia Nivoloni
dc.contributor.authorLips, Andrea
dc.contributor.authorMeneghim, Marcelo de Castro
dc.contributor.authorGranjeiro, José Mauro
dc.contributor.authorSeymen, Figen
dc.contributor.authorModesto, Adriana
dc.date.accessioned2020-04-17T12:53:09Z
dc.date.available2020-04-17T12:53:09Z
dc.date.issued2013
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalı
dc.description.abstractIntroduction The majority of tooth agenesis cases are mild (hypodontia) and typically not associated with the gene mutations linked to oligodontia. From this, we hypothesise that most cases of tooth agenesis fit a polygenic mode of inheritance, where several genes with small effects cause a variety of varying phenotypes. Materials and methods In this study, we looked at 18 not typically studied genes in this condition, to ascertain their contribution to hypodontia. Our study subjects consisted of 167 patients with hypodontia and their parents from two cohorts (one from Brazil and one from Turkey). An additional 465 DNA samples (93 cases with hypodontia and 372 controls without family history for tooth agenesis or oral clefts) from Brazil were also available for this study. Ninety-three single nucleotide polymorphisms that maximally represent the linkage disequilibrium structure of the genes for the 18 genes were selected and genotyped using Taqman chemistry. Chi square was used to test if genotype distributions were in Hardy–Weinberg equilibrium, and 24 markers that were in Hardy–Weinberg equilibrium and had allele frequencies higher than 5 % in a panel of 50 CEPH samples were further tested. Association between hypodontia and genetic variants was tested with the transmission disequilibrium test within the programme Family-Based Association Test (FBAT) and by using Chi square and Fisher’s exact tests. Alpha at a level of 0.05 was used to report results.
dc.identifier.citationVieira, Alexandre R., D'Souza, R., Mues, G., Deeley, K., Hsin, H., Küchler, Erika C. ... Modesto, A. (2013). Candidate gene studies in hypodontia suggest role for FGF3. European Archives of Paediatric Dentistry, 14(6), 405-410. https://dx.doi.org/10.1007/s40368-013-0010-2
dc.identifier.doi10.1007/s40368-013-0010-2
dc.identifier.endpage410
dc.identifier.issn1818-6300
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage405
dc.identifier.urihttps://dx.doi.org/10.1007/s40368-013-0010-2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5154
dc.identifier.volume14
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofEuropean Archives of Paediatric Dentistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectTooth Abnormalities
dc.subjectOdontogenesis
dc.subjectMSX1
dc.subjectPAX9
dc.subjectPITX2
dc.titleCandidate gene studies in hypodontia suggest role for FGF3
dc.typeArticle

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