Benign epilepsy with centrotemporal spikes: Is there a thalamocortical network dysfunction present?

Basit Öğe Kaydı
dc.authorid0000-0003-1513-6149
dc.contributor.authorŞanlıdağ, Burçin
dc.contributor.authorYayıcı Köken, Özlem
dc.contributor.authorÜlgen Temel, Esra
dc.contributor.authorArhan, Ebru
dc.contributor.authorAydın, Kürşad
dc.contributor.authorSerdaroğlu, Ayşe
dc.date.accessioned2020-07-09T12:00:42Z
dc.date.available2020-07-09T12:00:42Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: Benign epilepsy of childhood with centrotemporal spikes (BECTS) is one of the most frequently seen epileptic syndromes in childhood. It is characterized by centrotemporal spikes (CTS) on electroencephalography (EEG) that are typically activated by drowsiness and stage N2 sleep. The location, frequency, and amplitude of the spikes may vary in different EEG records of the same patient, supporting the presence of a global pathology rather than a focal one. Despite the well-known relation between BECTS and stage N2 sleep, the results of sleep studies have been diverse and have mainly focused on sleep cycles. The characteristics of sleep spindles in the interictal periods have not been studied well. Methods: A retrospective study involving patients with BECTS who were admitted to the Gazi University, Faculty of Medicine, Department of Pediatric Neurology from January 2017 to October 2018 was conducted herein. Patients with BECTS and age-matched controls who had stage N2 sleep records of 10 min were enrolled for spindle amplitude (peak-to-peak difference in spindle voltage), frequency (number of waveforms per second), and duration and density (number of spindle bursts/minute of stage N2 sleep). Results: A total of 30 children with BECTS and 20 age-matched healthy peers were enrolled in the study. There were no significant differences between the age and sex of the patients. Statistically significant lower mean values of the amplitude, and duration and density of the spindle activity were observed in patients with BECTS when compared to the controls (P: 0.034, P: 0.016, and 0.020, respectively). Additionally, the risk of epilepsy was found to increase by 1.9 %, by the decrease of the mean amplitude of the spindles by 1 mV when compared to control group. Conclusion: The interictal records of stage N2 sleep differed in the patients with BECTS when compared to the controls. Findings related to the stage N2 sleep of the present study may suggest a network problem involving the thalamus and thalamocortical pathways in patients with BECTS.
dc.identifier.citationŞanlıdağ, B., Yayıcı Köken, Ö., Ülgen Temel, E., Arhan, E., Aydın, K. ve Serdaroğlu, A. (2020). Benign epilepsy with centrotemporal spikes: Is there a thalamocortical network dysfunction present? Seizure - European Journal of Epilepsy, 79, 44-48. https://dx.doi.org/10.1016/j.seizure.2020.04.003
dc.identifier.doi10.1016/j.seizure.2020.04.003
dc.identifier.endpage48
dc.identifier.issn1059-1311
dc.identifier.issn1532-2688
dc.identifier.scopusqualityN/A
dc.identifier.startpage44
dc.identifier.urihttps://dx.doi.org/10.1016/j.seizure.2020.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5436
dc.identifier.volume79
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW.B. Saunders Company
dc.relation.ispartofSeizure - European Journal of Epilepsyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBenign Childhood Epilepsy With Centrotemporal Spikes (BECTS)
dc.subjectSleep Spindle
dc.subjectAmplitude
dc.subjectFrequency
dc.subjectDensity
dc.titleBenign epilepsy with centrotemporal spikes: Is there a thalamocortical network dysfunction present?
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Aydin, Kursad-2020.pdf
Boyut:
385.2 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu