HLA DRB1 alleles, IFN-gamma and TGF-beta Gene Variants in childhood ALL patients

Basit Öğe Kaydı
dc.authorid0000-0002-7129-5024
dc.contributor.authorOğuz, Süleyman Rüştü
dc.contributor.authorŞentürk Çiftçi, Hayriye
dc.contributor.authorGökçe, Müge
dc.contributor.authorÖğret, Yeliz
dc.contributor.authorKıvanç, Demet
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorAtay, Avni
dc.contributor.authorSavran Oğuz, Fatma
dc.contributor.authorAydın, Filiz
dc.date.accessioned2023-09-25T07:51:57Z
dc.date.available2023-09-25T07:51:57Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractObjectives Graft-versus-host disease (GvHD) is a complex clinical syndrome with organ dysfunction as a consequence of a severe immunological reaction mediated by mainly T cells after hematopoietic stem cell transplantation. Our aim is to evaluate the association of HLA-DRB1 alleles, IFN-gamma and TGF-beta gene variations, with childhood ALL (c-ALL) patients and with GvHD after transplantation. Methods This study included 30 high-risk c-ALL patients and 100 controls. HLA-DRB1 alleles were studied by the NGS method, and TGF-beta and IFN-gamma variations were studied by the PCR-RFLP method. Results The rates of HLA-DRB1*15 alleles and IFN-gamma CC genotype were significantly higher in c-ALL patients (p=0.004, p=0.036 respectively). Association of the HLA-DRB1*15 alleles with the TGF-beta TC genotype was found with a higher rate in the patient group (p=0.031). Association of the DRB1*04 allele with the IFN-gamma CC genotype was found with a higher rate in the patient group (p=0.028). Acute GvHD developed in eight of 19 patients who underwent transplantation. IFN-gamma CT was found to have a protective role in occurrence of aGvHD (p=0.044). Association of the DRB1*15 allele with IFN-gamma TT was found with a higher rate in a GvHD (p=0.050). Conclusions It is thought that polymorphism of HLA-DR15 and IFN-gamma CC may contribute to the development of c-ALL, while IFN-gamma CT might be protective for aGvHD.
dc.description.sponsorshipIstanbul Universityen_US
dc.identifier.citationOğuz, S. R., Şentürk Çiftçi, H., Gökçe, M., Öğret, Y., Kıvanç, D., Özdilli, K. ... Aydın, F. (2023). HLA DRB1 alleles, IFN-gamma and TGF-beta Gene Variants in childhood ALL patients. Turkish Journal of Biochemistry, 48(1), 80-87. https://doi.org/10.1515/tjb-2021-0202
dc.identifier.doi10.1515/tjb-2021-0202
dc.identifier.endpage87
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85130935305
dc.identifier.scopusqualityQ4
dc.identifier.startpage80
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0202
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11490
dc.identifier.volume48
dc.identifier.wos000799170900001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzdilli, Kürşat
dc.language.isoen
dc.publisherWalter de Gruyter GmbH
dc.relation.ispartofTurkish Journal of Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAcute Lymphoblastic Leukemia
dc.subjectaGvHD
dc.subjectCytokine
dc.subjectGenetic Polymorphism
dc.subjectHLA
dc.titleHLA DRB1 alleles, IFN-gamma and TGF-beta Gene Variants in childhood ALL patients
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Ozdilli-Kursat-2023.pdf
Boyut:
358.29 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu