Triggers and regulation: The gut microbiome in rheumatoid arthritis

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dc.authorid0000-0002-7919-1326
dc.authorid0000-0002-6782-2688
dc.contributor.authorMahroum, Naim
dc.contributor.authorSeida, Ravend
dc.contributor.authorShoenfeld, Yehuda
dc.date.accessioned2024-01-31T11:22:39Z
dc.date.available2024-01-31T11:22:39Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction Rheumatoid arthritis is a chronic inflammatory disease marked by systemic symptoms and joint degeneration. Interestingly, the development and progression of rheumatoid arthritis have been linked to the microbiome, notably the gut microbiome. Dysbiosis, an alteration in the gut microbiome, has been connected to the etiology and pathogenesis of rheumatoid arthritis. For instance, dysbiosis increases intestinal permeability and promotes the movement of bacteria and their products, which in turn triggers and aggravates systemic inflammation.Areas covered The correlation between the gut microbiome and RA. Triggers of RA including dysbiosis. The therapeutic potential of the gut microbiome in RA due to its critical function in influencing the immune response. The fecal microbiota transplantation (FMT), a therapeutic strategy that involves the transfer of healthy fecal microbiota from a donor to a recipient, has produced encouraging results in the treatment of several autoimmune illnesses, including rheumatoid arthritis.Expert opinion The role of the gut microbiome in RA is critical and serves as a basis for etiology and pathogenesis, as well as having therapeutic implications. In our opinion, FMT is an excellent example of this correlation. Still, more investigations and well-designed studies are needed in order to make firm conclusions and recommendations.
dc.description.sponsorshipIstanbul Medipol Universityen_US
dc.identifier.citationMahroum, N., Seida, R. ve Shoenfeld, Y. (2023). Triggers and regulation: The gut microbiome in rheumatoid arthritis. Expert Review of Clinical Immunology, 19(12), 1449-1456. https://dx.doi.org/10.1080/1744666X.2023.2260103
dc.identifier.doi10.1080/1744666X.2023.2260103
dc.identifier.endpage1456
dc.identifier.issn1744-666X
dc.identifier.issn1744-8409
dc.identifier.issue12
dc.identifier.pmid37712213
dc.identifier.scopus2-s2.0-85171782784
dc.identifier.scopusqualityQ2
dc.identifier.startpage1449
dc.identifier.urihttps://dx.doi.org/10.1080/1744666X.2023.2260103
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12226
dc.identifier.volume19
dc.identifier.wos001069525400001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMahroum, Naim
dc.institutionauthorSeida, Ravend
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofExpert Review of Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutoimmunity
dc.subjectFecal Microbial Transplantation
dc.subjectGut Microbiome
dc.subjectMicrobiome
dc.subjectRheumatoid Arthritis
dc.titleTriggers and regulation: The gut microbiome in rheumatoid arthritis
dc.typeArticle

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