DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders

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dc.authorid0000-0001-6141-8265
dc.contributor.authorÇelik, Önder
dc.contributor.authorAcet, Mustafa
dc.contributor.authorİmren, Aytaç
dc.contributor.authorÇelik, Nilüfer
dc.contributor.authorErşahin, Aynur
dc.contributor.authorAktün, Lebriz Hale
dc.contributor.authorOtlu, Barış
dc.contributor.authorÇelik, Sudenaz
dc.contributor.authorÇalıskan, Eray
dc.contributor.authorÜnlü, Cihat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:32Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:32Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000423956200002
dc.descriptionPubMed ID: 29278227
dc.description.abstractObjective: The study was planned to investigate whether DHEA supplementation had an impact on endometrial receptivity in women who were poor responders (POR). Material and Methods: Twenty-eight POR women who were undergoing hysteroscopy and five fertile control subjects were included. The POR women were equally subdivided into two separate groups as patients who were currently using DHEA and those who were not. Endometrial samples of the subjects were obtained during hysteroscopy at the late follicular phase. Expression levels of endometrial HOXA-10, HOXA-11, and LIF mRNA were measured with the using real-time polymerase chain reaction. Spontaneous clinical pregnancy rates were also noted. Results: Compared with POR women who were not given DHEA, upregulated endometrial HOXA-10 (7.33-fold) and HOXA-11 (2.39-fold) mRNA expression were detected in POR women on DHEA. The increase in HOXA-10 mRNA was significant (p<0.03). The fold increase in HOXA-11 mRNA was found as 2.39, which indicated a positive upregulation. However, this fold increment was insignificant (p<0.45). An insignificant increase in spontaneous clinical pregnancy rates in POR women on DHEA (53.3%) was observed compared with POR women who were not given DHEA (43.8%). Conclusion: Oral DHEA supplementation in POR upregulates endometrial HOXA-10 mRNA expression, which is known to positively modulate endometrial receptivity.
dc.description.sponsorshipTurkish German Gynecologic Research and Education Foundation for HOXA and LIF genes kitsen_US
dc.identifier.citationÇelik, Ö., Acet, M., İmren, A., Çelik, N., Erşahin, A., Aktün, L. H. ... Ünlü C. (2017). DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders. Journal of the Turkish-German Gynecological Association, 18(4), 160-166. https://dx.doi.org/10.4274/jtgga.2017.0054
dc.identifier.doi10.4274/jtgga.2017.0054
dc.identifier.endpage166
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage160
dc.identifier.urihttps://dx.doi.org/10.4274/jtgga.2017.0054
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3333
dc.identifier.volume18
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.ispartofJournal of the Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndometrium
dc.subjectDHEA
dc.subjectHomeobox Genes
dc.subjectPoor Responder
dc.titleDHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders
dc.typeArticle

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