Does metoclopramide exposure alter endometrial receptivity and decrease pregnancy rates?

Basit Öğe Kaydı
dc.authorid0000-0003-0128-6947
dc.contributor.authorÇekmez, Yasemin
dc.contributor.authorKorkmaz, Vakkas
dc.contributor.authorÇakır, Aslı
dc.contributor.authorGöçmen, Ahmet
dc.contributor.authorErgün, Yusuf
dc.contributor.authorGülşen, Serdar
dc.contributor.authorAkpak, Yaşam Kemal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:33Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:33Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000375027200028
dc.descriptionPubMed ID: 26421644
dc.description.abstractObjective: The aim of this study was to investigate the effect of metoclopramide on endometrial receptivity with an immunohistochemical investigation of integrin beta 3 expression in pregnant rats. Materials and methods: In the present study, the pregnant mice administrated by different doses of metoclopramide were used to explore the effect of metoclopramide on embryo implantation, especially on the endometrial receptivity. Results: The statistical results showed that the number of implanted embryos was gradually declining along the increasing dose of metoclopramide. When the administrated dose of metoclopramide was 3 mg/kg per day, great changes were observed in the exposed uterine morphology and down-regulated integrin beta 3 were also found in high dose metoclopramide-exposed mice. Conclusion: Metoclopramide exposure, especially in high doses may alter endometrial receptivity by effecting integrin expression on decidual tissue which can decrease pregnancy rates. This drug should only be recommended for use during pregnancy when benefit outweighs the risk.
dc.identifier.citationÇekmez, Y., Korkmaz, V., Çakır, A., Göçmen, A., Ergün, Y., Gülşen, S. ... Akpak, Y. K. (2016). Does metoclopramide exposure alter endometrial receptivity and decrease pregnancy rates? Journal Of Maternal-Fetal & Neonatal Medicine, 29(16), 2703-2706. https://dx.doi.org/10.3109/14767058.2015.1102221
dc.identifier.doi10.3109/14767058.2015.1102221
dc.identifier.endpage2706
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue16
dc.identifier.scopusqualityQ2
dc.identifier.startpage2703
dc.identifier.urihttps://dx.doi.org/10.3109/14767058.2015.1102221
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3189
dc.identifier.volume29
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAbortion
dc.subjectDecidua
dc.subjectIntegrin
dc.subjectMetoclopramide
dc.subjectPregnancy
dc.titleDoes metoclopramide exposure alter endometrial receptivity and decrease pregnancy rates?
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Cakir-Asli 2016.pdf
Boyut:
1021.65 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu