Can neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio at day+100 be used as a prognostic marker in multiple myeloma patients with autologous transplantation?

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dc.authorid0000-0001-9636-4113
dc.contributor.authorSolmaz Medeni, Şerife
dc.contributor.authorAcar, Celal
dc.contributor.authorOlgun, Aybüke
dc.contributor.authorAcar, Alev
dc.contributor.authorSeyhanlı, Ahmet
dc.contributor.authorTaşkıran, Emin
dc.contributor.authorSevindik, Ömür Gökmen
dc.contributor.authorAlacacıoğlu, İnci
dc.contributor.authorPişkin, Özden
dc.contributor.authorÖzcan, Mehmet Ali
dc.contributor.authorDemirkan, Fatih
dc.contributor.authorÜndar, Bülent
dc.contributor.authorÖzsan, Güner Hayri
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:15Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:15Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000445328900014
dc.descriptionPubMed ID: 30053318
dc.description.abstractBackground: Recent reports have showed that neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are predictors of progression-free survival (PFS) and overall survival (OS) in many types of cancer. This study evaluates the predictive value of NLR, MLR, and PLR for survival in MM patients treated with to ASCT. Methods: A set of data consisting of 150 patients who underwent autologous stem cell transplantation (ASCT) for MM was collected retrospectively. The prognostic value of NLR, MLR, and PLR was investigated with Kaplan-Meier method. Results: The prognostic value of NLR, MLR, and PLR was analyzed by a receiver operating characteristic (ROC) curve established to determine the cutoff. These cutoff values of NLR, PLR, and MLR were found 1.46, 86, and 0.27, respectively, on the 100th day of post-transplantation period. The overall survival (OS) and the post-transplantation OS of the patients with high NLR, MLR, and PLR levels on the 100th day of post-transplantation were shorter than the other group (P = 0.05, P = 0.018 [NLR], P = 0.05, P = 0.002 [MLR], P = 0.000, P = 0.001 [PLR]). The post-transplantation progression-free survival (PFS) of the patients with high NLR, MLR, and PLR levels on the 100th day of post-transplantation was shorter as well (P = 0.036, P = 0.001, P = 0.001, respectively). Conclusion: As increased NLR, MLR, and PLR predicted poor clinical outcome in MM patients with autologous transplantation in this study, they may serve as cost-effective and rapidly available prognostic biomarkers for these patients.
dc.identifier.citationSolmaz Medeni, Ş., Acar, C., Olgun, A., Acar, A., Seyhanlı, A., Taşkıran, E. ... Özsan, G. H. (2018). Can neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio at day+100 be used as a prognostic marker in multiple myeloma patients with autologous transplantation? Clinical Transplantation, 32(9). https://dx.doi.org/10.1111/ctr.13359
dc.identifier.doi10.1111/ctr.13359
dc.identifier.issn0902-0063
dc.identifier.issn1399-0012
dc.identifier.issue9
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1111/ctr.13359
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1926
dc.identifier.volume32
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.relation.ispartofClinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMonocyte Lymphocyte Ratio (MLR)
dc.subjectMultiple Myeloma
dc.subjectNeutrophil-to-Lymphocyte Ratio (NLR)
dc.subjectPlatelet-to-Lymphocyte Ratio (PLR)
dc.titleCan neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio at day+100 be used as a prognostic marker in multiple myeloma patients with autologous transplantation?
dc.typeArticle

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