Interleukin-35 levels in patients with stable coronary artery disease

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dc.authorid0000-0001-9338-8152
dc.authorid0000-0001-6643-9364
dc.contributor.authorOflar, Ersan
dc.contributor.authorŞahin, Mustafa Hakan
dc.contributor.authorDemir, Bülent
dc.contributor.authorErtuğrul, Abdulcelil Sait
dc.contributor.authorÖztaş, Didem Melis
dc.contributor.authorBeyaz, Metin Onur
dc.contributor.authorUğurlucan, Murat
dc.contributor.authorTurhan Çağlar, Fatma Nihan
dc.date.accessioned2022-03-21T13:19:51Z
dc.date.available2022-03-21T13:19:51Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground: It has been shown that interleukin-35 (IL-35) subunits are strongly expressed in atherosclerotic plaques in humans. Therefore, it is considered to play a role in atherosclerosis. Objectives: In this study, IL-35 levels were compared with the control group in patients with stable coronary artery disease (CAD), and the association between IL-35 levels and the lesion type, lesion severity and extension was investigated with the Gensini score (GS) and the Syntax score (SS) in the patient group. Methods: Sixty patients (18 female and 42 male) with CAD diagnosed by coronary angiography, who presented with typical chest pain and positive noninvasive cardiac stress test, and 46 patients (18 female and 28 male) with normal coronary lumenogram, were included in this study. Gensini and Syntax scores were calculated in the patient group, and these values were compared with IL-35 levels. Non-normally distributed variables were analyzed by the Mann-Whitney U test, whereas normally distributed parameters were assessed by Student’s t-test. The difference between categorical variables were evaluated by the Chi-square or Fisher test. P-values<0.05 were considered as statistically significant. Results: No significant differences were observed between patients and the control group in terms of demographic characteristics and laboratory findings. Compared to the control group, IL-35 levels of the CAD group were considerably lower (36.9±63.9 ng/ml vs. 33.2±13.2 ng/ml, p<0.008). Although not statistically significant, IL-35 levels were higher in patients with low SS than among those with high SS (33.2±13.7 vs. 31.8±8.9, p=0.51). The IL-35 values of the patients with high GS were significantly lower than in patients with low GS (35±17.4 vs. 30.7±8.6, p=0.043). Conclusion: It has been shown that IL-35 levels can be a new biomarker for stable CAD, and IL-35 is associated with the extension of CAD.
dc.identifier.citationOflar, E., Şahin, M. H., Demir, B., Ertuğrul, A. S., Öztaş, D. M., Beyaz, M. O. ... Turhan Çağlar, F. N. (2022). Interleukin-35 levels in patients with stable coronary artery disease. Arquivos Brasileiros de Cardiologia, 118(2), 400-408. https://doi.org/10.36660/abc.20200945
dc.identifier.doi10.36660/abc.20200945
dc.identifier.endpage408
dc.identifier.issn0066-782X
dc.identifier.issue2
dc.identifier.pmid35262572
dc.identifier.scopus2-s2.0-85126075970
dc.identifier.scopusqualityQ3
dc.identifier.startpage400
dc.identifier.urihttps://doi.org/10.36660/abc.20200945
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9147
dc.identifier.volume118
dc.identifier.wos000787760400005en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBeyaz, Metin Onur
dc.institutionauthorUğurlucan, Murat
dc.language.isoen
dc.publisherArquivos Brasileiros de Cardiologia
dc.relation.ispartofArquivos Brasileiros de Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAtherosclerosis
dc.subjectCoronary Artery Disease
dc.subjectGensini Score
dc.subjectInterleukin-35
dc.subjectSyntax Score
dc.titleInterleukin-35 levels in patients with stable coronary artery disease
dc.title.alternativeNíveis de ınterleucina-35 em pacientes com doença arterial coronariana estável
dc.typeArticle

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