Are there any new reliable markers to detect renal injury in obese children?

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dc.authorid0000-0003-1333-2648
dc.contributor.authorBostan Gayret, Özlem
dc.contributor.authorTaşdemir, Mehmet
dc.contributor.authorErol, Meltem
dc.contributor.authorNacaroğlu, Hikmet Tekin
dc.contributor.authorZengi, Oğuzhan
dc.contributor.authorYiğit, Özgül
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:50Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:50Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000439906200001
dc.descriptionPubMed ID: 30035656
dc.description.abstractAim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children.Methods: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were measured, and homeostasis model assessment -insulin resistance (HOMA-IR) was calculated. The urine albumin/creatinine ratio was calculated. The serum and urine KIM-1, NGAL, OPN, and MMP-9 levels were measured.Results: Serum cystatin-C, triglyceride, and homeostasis model assessment-insulin resistance (HOMA-IR) index were found to be significantly higher in the obese group (p=.0001), and high-density lipoprotein (HDL) cholesterol was found to be significantly lower (p=.019) in the obese group. No significant differences were found in serum KIM-1, NGAL, OPN or MMP-9 levels between groups (p>.05). No significant differences were found in urine KIM-1 and MMP-9 levels (p>.05), Urine NGAL, and OPN levels were found significantly higher in obese groups (p<.05).Conclusions: According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population.
dc.description.sponsorshipBagcilar Training and Research Hospital Revolving Fundsen_US
dc.description.sponsorshipThis research was supported by Bagcilar Training and Research Hospital Revolving Funds.en_US
dc.identifier.citationBostan Gayret, Ö., Taşdemir, M., Erol, M., Nacaroğlu, H.,Zengi, O. ve Yiğit, Ö. (2018). Are there any new reliable markers to detect renal injury in obese children? Renal Failure, 40(1), 416-422. https://dx.doi.org/10.1080/0886022X.2018.1489284
dc.identifier.doi10.1080/0886022X.2018.1489284
dc.identifier.endpage422
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage416
dc.identifier.urihttps://dx.doi.org/10.1080/0886022X.2018.1489284
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3745
dc.identifier.volume40
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCystatin C
dc.subjectKIM-1
dc.subjectNGAL
dc.subjectOPN
dc.subjectMMP-9
dc.subjectObese
dc.subjectChildren
dc.titleAre there any new reliable markers to detect renal injury in obese children?
dc.typeArticle

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