The role of oxidant status on the etiopathogenesis of unexplained infertility and intracytoplasmic sperm injection - embryo transfer success: A case-control study

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dc.authorid0000-0002-4606-9965
dc.contributor.authorŞentürk, Raziye
dc.contributor.authorTola, Esra Nur
dc.contributor.authorBozkurt, Mustafa
dc.contributor.authorKumbul Doğuç, Duygu
dc.date.accessioned2023-01-18T08:58:06Z
dc.date.available2023-01-18T08:58:06Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractThe present study aims to evaluate the role of follicular fluid (FF) and serum (s) total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) on the etiopathogenesis of unexplained infertility (UI) and intracytoplasmic sperm injection-embryo transfer (ICSI-ET) success. Twenty UI patients and 20 controls with male factor undergoing an ICSI-ET cycle were recruited. FF samples aspirated from mature follicles and blood samples collected just before the oocyte retrieval were stored until analysis. Embriyo quality and implantation, clinical pregnancy and living birth rates were evaluated. FF-TOS and FF-OSI of the UI patients were higher than the control group. s-TOS and s-OSI were significantly increased in the UI group compared to the control group. However, only s-TOS was positively associated with UI diagnosis after age-adjustment. FF-OSI was negatively associated with embryo quality in the UI group (but not in the whole group) after age-adjustment. No significant effect of TAS, TOS, and OSI on implantation, clinical pregnancy and live birth rate was observed. In conclusion, especially s-TOS can have a partial role in the etiopathogenesis of UI. High FF-OSI can decrease the quality of embryo in patients with UI.Impact statement What is already known? Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI), which is the ratio of TOS to TAS, provide a broad overview of redox status. What do the results of this study add? An elevated serum TOS (s-TOS) was associated with UI after age-adjustment. Follicular fluid OSI (FF-OSI) was negatively associated with embryo quality and embryo score in the UI group (but not in the whole group) after age-adjustment. No significant effect of TAS, TOS, and OSI was observed on implantation, clinical pregnancy, and live birth rate. What are the implications of these findings for clinical practice and/or further research? Evaluation of FF-OSI in women with unexplained infertility can be considered to predict embryo quality. Further studies that evaluate antioxidant agents to decrease oxidative stress in UI and its' clinical implications are warranted.
dc.description.sponsorshipScientific Research Unit of Suleyman Demirel Universityen_US
dc.identifier.citationŞentürk, R., Tola, E. N., Bozkurt, M. ve Kumbul Doğuç, D. (2022). The role of oxidant status on the etiopathogenesis of unexplained infertility and intracytoplasmic sperm injection - embryo transfer success: A case-control study. Journal of Obstetrics and Gynaecology, 42(5), 1312-1318. https://dx.doi.org/10.1080/01443615.2021.1960294
dc.identifier.doi10.1080/01443615.2021.1960294
dc.identifier.endpage1318
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue5
dc.identifier.pmid34842027
dc.identifier.scopus2-s2.0-85120034525
dc.identifier.scopusqualityQ3
dc.identifier.startpage1312
dc.identifier.urihttps://dx.doi.org/10.1080/01443615.2021.1960294
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10325
dc.identifier.volume42
dc.identifier.wos000723539400001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTola, Esra Nur
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectTotal Oxidant Status
dc.subjectTotalantioxidant Status
dc.subjectOxidativestress Index
dc.subjectUnexplainedinfertility
dc.subjectIntra-Cytoplasmicsperm Injection Success
dc.titleThe role of oxidant status on the etiopathogenesis of unexplained infertility and intracytoplasmic sperm injection - embryo transfer success: A case-control study
dc.typeArticle

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