Evaluation of HOTAIR, HOXD8, HOXD9, HOXD11 gene expression levels in Turkish patients with acute and chronic myeloid leukemia: a single center experience

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dc.contributor.authorSaraymen, Esma
dc.contributor.authorErdem, Yakut
dc.contributor.authorAkalın, Hilal
dc.contributor.authorTaşçıoğlu, Nazife
dc.contributor.authorSaraymen, Berkay
dc.contributor.authorKaynar, Leylagül
dc.contributor.authorÖzkul, Yusuf
dc.date.accessioned2025-12-16T12:51:52Z
dc.date.available2025-12-16T12:51:52Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractHomeobox (HOX) transcript antisense RNA (HOTAIR) and HOX genes are reported to be more expressed in various cancers in humans in recent studies. The role of HOTAIR and HOXD genes in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) is not well known. In this study, expression levels of HOXD8, HOXD9 and HOXD11 from HOXD gene family and HOTAIR were determined from peripheral blood samples of 30 AML and 30 CML patients and 20 healthy volunteers by quantitative Real Time PCR. We determined that the expression levels of HOXD9 and HOXD11 in the AML patients were significantly lower than the control group (p<0.001 and p=0.002, respectively). There was no significant difference in the expression levels of HOTAIR and HOXD8 when compared to the control group. In the CML patients there was a significant increase in the expression level of HOTAIR when compared to the control group (p=0.002). The expression levels of HOXD9 and HOXD11 were found to be significantly lower than the control group (p<0.001). Our study showed that HOTAIR may not be a biomarker in the diagnosis and is not significantly correlated with the clinicopathological prognostic characteristics of AML. Additionally; it can be said that HOTAIR is oncogenic by suppressing the expression of HOXD9 and HOXD11 but not HOXD8 in CML patients. The expression profiles of HOTAIR may be a potential biomarker in the diagnosis of CML patients in predicting and monitoring drug resistance.
dc.identifier.citationSaraymen, E., Erdem, Y., Akalın, H., Taşçıoğlu, N., Saraymen, B., Kaynar, L. ... Özkul, Y. (2024). Evaluation of HOTAIR, HOXD8, HOXD9, HOXD11 gene expression levels in Turkish patients with acute and chronic myeloid leukemia: a single center experience. Cellular and Molecular Biology, 70(11), 39-45. http://dx.doi.org/10.14715/cmb/2024.70.11.5
dc.identifier.doi10.14715/cmb/2024.70.11.5
dc.identifier.endpage45
dc.identifier.issn0145-5680
dc.identifier.issue11
dc.identifier.pmid39707783
dc.identifier.scopus2-s2.0-85213024791
dc.identifier.scopusqualityQ4
dc.identifier.startpage39
dc.identifier.urihttp://dx.doi.org/10.14715/cmb/2024.70.11.5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13341
dc.identifier.volume70
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaynar, Leylagül
dc.institutionauthorid0000-0002-2035-9462
dc.language.isoen
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rightsAttribution 4.0 International
dc.subjectAML
dc.subjectCML
dc.subjectHOTAIR
dc.subjectHOXD11
dc.subjectHOXD8
dc.subjectHOXD9
dc.titleEvaluation of HOTAIR, HOXD8, HOXD9, HOXD11 gene expression levels in Turkish patients with acute and chronic myeloid leukemia: a single center experience
dc.typeArticle

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