Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences

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dc.authorid0000-0003-0906-4417
dc.authorid0000-0002-6308-1763
dc.contributor.authorScheltema, Matthijs J.
dc.contributor.authorO'Brien, Tim J.
dc.contributor.authorvan den Bos, Willemien
dc.contributor.authorde Bruin, Daniel M.
dc.contributor.authorV. Davalos, Rafael
dc.contributor.authorvan den Geld, Cees W. M.
dc.contributor.authorLaguna, Maria Pilar
dc.contributor.authorNeal, Robert E.
dc.contributor.authorVarkarakis, Ioannis M.
dc.contributor.authorSkolarikos, Andreas
dc.contributor.authorStricker, Phillip D.
dc.contributor.authorde Reijke, Theo. M.
dc.contributor.authorArena, Christopher B.
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:32Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:32Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.descriptionWOS: 000471007100001
dc.descriptionPubMed ID: 31217820
dc.description.abstractBackground: At present, it is not possible to predict the ablation zone volume following irreversible electroporation (IRE) for prostate cancer (PCa). This study aimed to determine the necessary electrical field threshold to ablate human prostate tissue in vivo with IRE. Methods: In this prospective multicenter trial, patients with localized PCa were treated with IRE 4 weeks before their scheduled radical prostatectomy. In 13 patients, numerical models of the electrical field were generated and compared with the ablation zone volume on whole-mount pathology and T2-weighted magnetic resonance imaging (MRI) sequences. Volume-generating software was used to calculate the ablation zone volumes on histology and MRI. The electric field threshold to ablate prostate tissue was determined for each patient. Results: A total of 13 patients were included for histological and simulation analysis. The median electrical field threshold was 550 V/cm (interquartile range 383-750 V/cm) for the software-generated histology volumes. The median electrical field threshold was 500 V/cm (interquartile range 386-580 V/cm) when the ablation zone volumes were used from the follow-up MRI. Conclusions: The electrical field threshold to ablate human prostate tissue in vivo was determined using whole-mount pathology and MRI. These thresholds may be used to develop treatment planning or monitoring software for IRE prostate ablation; however, further optimization of simulation methods are required to decrease the variance that was observed between patients.
dc.description.sponsorshipCure for Cancer charity foundation; Cures within Reach and the Endourological Societyen_US
dc.description.sponsorshipThis work was supported by the Cure for Cancer charity foundation, Cures within Reach and the Endourological Societyen_US
dc.identifier.citationScheltema, M. J., O'Brien, T. J., van den Bos, W., de Bruin, D. M., V. Davalos, R., van den Geld, C. W. M. ... de la Rosette, J. J. M. C. H. (2019). Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences. Therapeutic Advances in Urology, 11. https://dx.doi.org/10.1177/1756287219852305
dc.identifier.doi10.1177/1756287219852305
dc.identifier.issn1756-2872
dc.identifier.issn1756-2880
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1177/1756287219852305
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1632
dc.identifier.volume11
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications LTD
dc.relation.ispartofTherapeutic Advances in Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://www.creativecommons.org/licenses/by-nc/4.0/*
dc.subjectElectrical Field
dc.subjectFocal Therapy
dc.subjectIrreversible Electroporation
dc.subjectProstate
dc.subjectProstate Cancer
dc.subjectSimulation
dc.titleNumerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences
dc.typeArticle

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