Lesional resective epilepsy surgery in childhood: Comparison of two decades and long-term seizure outcome from a single center

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dc.authorid0000-0003-1447-9051
dc.contributor.authorGünbey, Ceren
dc.contributor.authorBilginer, Burçak
dc.contributor.authorKarlı Oğuz, Kader
dc.contributor.authorSöylemezoğlu, Figen
dc.contributor.authorErgün, Eser Lay
dc.contributor.authorAkalan, Nejat
dc.contributor.authorTopçu, Meral
dc.contributor.authorTuranlı, Güzide
dc.contributor.authorYalnızoğlu, Dilek
dc.date.accessioned2022-05-12T11:26:23Z
dc.date.available2022-05-12T11:26:23Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractObjective: Epilepsy surgery has shown efficacy in children. We aimed to assess long-term seizure outcome in children who underwent epilepsy surgery and determine predictive factors for seizure freedom.& nbsp;Methods: This is a retrospective study of 196 children who underwent epilepsy surgery between 1994 and 2015 and had a minimum postoperative follow-up of 5 years.& nbsp;Results: The median age at the time of surgery was 9.5 (0.08-19.8) years; 110 (56.1%) had temporal, 62 (31.6%) had extratemporal resections, and 24 (12.2%) had hemispheric surgery. The duration of postsurgical follow-up was between 5 and 20 years (mean +/- SD: 7 +/- 3.2). Overall, 129 of 196 (65.8%) patients had Engel class I outcome at final visit. Among patients who underwent temporal, extratemporal and hemispheric surgery; 84 of 110 (76.4%), 34 of 62 (54.8%), and 11 of 24 (45.8%) patients had complete seizure freedom, respectively (p: 0.016). Patients with tumors had the best outcome, with 83.1% seizure freedom. The number of preoperative antiseizure medications (OR 3.19, 95% CI 1.07-9.48), the absence of postoperative focal epileptiform discharges (OR 8.98, 95% CI 4.07-19.79) were independent predictors of seizure freedom. Across two decades, the age at surgery was decreased (p: 0.003), overall seizure freedom (61.8% vs 68%) did not differ. In the past decade, a higher proportion of malformations of cortical development was operated (14.7% vs 35.9%, p: 0.007).& nbsp;Significance: Our findings showed favorable long-term seizure outcome in children who underwent epilepsy surgery. The results are encouraging for developing centers with limited resources to establish pediatric epilepsy programs.
dc.identifier.citationGünbey, C., Bilginer, B., Karlı Oğuz, K., Söylemezoğlu, F., Ergün, E. L., Akalan, N. ... Yalnızoğlu, D. (2022). Lesional resective epilepsy surgery in childhood: Comparison of two decades and long-term seizure outcome from a single center. Epilepsy Research, 181. https://doi.org/10.1016/j.eplepsyres.2022.106882
dc.identifier.doi10.1016/j.eplepsyres.2022.106882
dc.identifier.issn0920-1211
dc.identifier.issn1872-6844
dc.identifier.pmid35168000
dc.identifier.scopus2-s2.0-85124478734
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.eplepsyres.2022.106882
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9436
dc.identifier.volume181
dc.identifier.wos000786607000015en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkalan, Nejat
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEpilepsy Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectChildren
dc.subjectEpilepsy Surgery
dc.subjectExtratemporal Resections
dc.subjectHemispheric Surgery
dc.subjectLong-Term Seizure Outcome
dc.subjectTemporal Resections
dc.titleLesional resective epilepsy surgery in childhood: Comparison of two decades and long-term seizure outcome from a single center
dc.typeArticle

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