Best dilution of the best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults

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dc.authorid0000-0002-7885-0537
dc.authorid0000-0001-5057-0405
dc.authorid0000-0002-7022-913X
dc.contributor.authorÜstüner, Pelin
dc.contributor.authorBalevi, Ali
dc.contributor.authorÖzdemir, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:58Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:58Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.descriptionWOS: 000416888400013
dc.descriptionPubMed ID: 28489468
dc.description.abstractPurpose: To evaluate and compare the clinical efficacy, dermoscopic results and safety of triamcinolone acetonide (TA) and betamethasone dipropionate (BD) injections at different concentrations in localized scalp and beard alopecia. Methods: Intralesional injection of BD or TA in three different dilutions; 1/4, 1/8, 1/12 (BD1, BD2, BD3, TA1, TA2, TA3) and Saline (control) was randomly applied to a total of 231 alopecia patches in 83 patients every four weeks in a maximum of six sessions until a hair regrowth score of 4 was achieved. The number of required sessions, sixth-month hair regrowth scores, treatment success rates and dermoscopic data were investigated. Results: The mean number of required sessions were similar and significantly lower in BD1 and TA1 being 4.21 +/- 1.12 and 3.74 +/- 0.99, respectively. Dermoscopic examinations revealed similar terminal hair growth rations in Saline (30.3%), BD1 (44.4%) and TA1 (42.9%). However, sixth-month hair regrowth scores, overall treatment success rates and percentage of terminal hair regrowth were similar in BD1 and TA1. However, adverse effects were more common in TA groups (24.3%) than in BD groups (10.6%) at the sixth month. Conclusions: BD 1= 4 dilution (1.25 mg/dL) seems best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults.
dc.identifier.citationÜstüner, P., Balevi, E. ve Özdemir, M. (2017). Best dilution of the best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults. Journal of Dermatological Treatment, 28(8), 753-761. https://dx.doi.org/10.1080/09546634.2017.1329497
dc.identifier.doi10.1080/09546634.2017.1329497
dc.identifier.endpage761
dc.identifier.issn0954-6634
dc.identifier.issn1471-1753
dc.identifier.issue8
dc.identifier.scopusqualityQ1
dc.identifier.startpage753
dc.identifier.urihttps://dx.doi.org/10.1080/09546634.2017.1329497
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3084
dc.identifier.volume28
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd.
dc.relation.ispartofJournal of Dermatological Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlopecia
dc.subjectAlopecia Areata
dc.subjectBetamethasone Dipropionate
dc.subjectInjections
dc.subjectIntralesional
dc.subjectTriamcinolone Acetonide
dc.titleBest dilution of the best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults
dc.typeArticle

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