Axillary microbiota is associated with cognitive impairment in parkinson's disease patients

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dc.authorid0000-0001-7566-1063
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-2752-1223
dc.contributor.authorArıkan, Muzaffer
dc.contributor.authorYıldız, Zeynep
dc.contributor.authorKahraman Demir, Tuğçe
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorŞen, Aysu
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYıldırım, Süleyman
dc.date.accessioned2022-03-01T06:01:32Z
dc.date.available2022-03-01T06:01:32Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractCognitive impairment (CI) is among the most common non-motor symptoms of Parkinson's disease (PD), with a substantially negative impact on patient management and outcome. The development and progression of CI exhibits high interindividual variability, which requires better diagnostic and monitoring strategies. PD patients often display sweating disorders resulting from autonomic dysfunction, which has been associated with CI. Because the axillary microbiota is known to change with humidity level and sweat composition, we hypothesized that the axillary microbiota of PD patients shifts in association with CI progression, and thus can be used as a proxy for classification of CI stages in PD. We compared the axillary microbiota compositions of 103 PD patients (55 PD patients with dementia [PDD] and 48 PD patients with mild cognitive impairment [PD-MCI]) and 26 cognitively normal healthy controls (HC). We found that axillary microbiota profiles differentiate HC, PD-MCI, and PDD groups based on differential ranking analysis, and detected an increasing trend in the log ratio of Corynebacterium to Anaerococcus in progression from HC to PDD. In addition, phylogenetic factorization revealed that the depletion of the Anaerococcus, Peptoniphilus, and W5053 genera is associated with PD-MCI and PDD. Moreover, functional predictions suggested significant increases in myo-inositol degradation, ergothioneine biosynthesis, propionate biosynthesis, menaquinone biosynthesis, and the proportion of aerobic bacteria and biofilm formation capacity, in parallel to increasing CI. Our results suggest that alterations in axillary microbiota are associated with CI in PD. Thus, axillary microbiota has the potential to be exploited as a noninvasive tool in the development of novel strategies.
dc.description.sponsorshipSuleyman Yildirim from the Scientific and Technological Research Council of Turkey (TUBITAK)en_US
dc.identifier.citationArıkan, M., Yıldız, Z., Kahraman Demir, T., Helvacı Yılmaz, N., Şen, A., Hanoğlu, L. ... Yıldırım, S. (2022). Axillary microbiota is associated with cognitive impairment in parkinson's disease patients. Microbiology Spectrum, 10(1). https://doi.org/10.1128/spectrum.02358-21
dc.identifier.doi10.1128/spectrum.02358-21
dc.identifier.issn2165-0497
dc.identifier.issue1
dc.identifier.pmid35138147
dc.identifier.scopus2-s2.0-85124285933
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1128/spectrum.02358-21
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9034
dc.identifier.volume10
dc.identifier.wos000766015800208en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorArıkan, Muzaffer
dc.institutionauthorYıldız, Zeynep
dc.institutionauthorKahraman Demir, Tuğçe
dc.institutionauthorHelvacı Yılmaz, Nesrin
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorYıldırım, Süleyman
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofMicrobiology Spectrumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject16S Sequencing
dc.subjectArmpit
dc.subjectArmpit Microbiota
dc.subjectAxillary Microbiota
dc.subjectCognitive Impairment
dc.subjectDementia
dc.subjectParkinson's Disease
dc.subjectSkin Microbiota
dc.titleAxillary microbiota is associated with cognitive impairment in parkinson's disease patients
dc.typeArticle

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