Solitary metastasis mimicking glioblastoma in a patient with fahr’s disease

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dc.contributor.authorTaydaş, Onur
dc.contributor.authorHas, Büşra
dc.contributor.authorSakçı, Zakir
dc.contributor.authorOğul, Hayri
dc.contributor.authorKantarcı, Mecit
dc.date.accessioned2025-12-01T10:55:40Z
dc.date.available2025-12-01T10:55:40Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractFahr’s disease is defined as the accumulation of bilateral idiopathic calcification in the basal ganglia, dentate nucleus, and centrum semiovale. The coexistence of Fahr’s disease and intracranial tumors is extremely rare, with only five cases documented in the literature. This study aimed to present a rare case, discussing both similarities and differences with previously reported cases. A 70-year-old female patient presented to our hospital with a progressive headache over the past month. Brain magnetic resonance imaging (MRI) with intravenous contrast was performed for further evaluation. Bilateral basal ganglia, thalamus, and dentate nuclei showed calcifications consistent with Fahr’s disease. After excluding toxic, infectious, and endocrine causes of calcification, the patient was diagnosed with Fahr’s disease. Magnetic resonance imaging also revealed a midline localized, irregularly contoured, and heterogeneously intense mass with contrast enhancement at the centrum semiovale level, accompanied by peripheral edema. Radiologically, the mass resembled a high-grade glioma or metastasis, and the presence of a lipid peak further suggested metastasis. Based on radiological findings, the patient was diagnosed with brain metastasis of breast carcinoma. The patient received chemotherapy for metastasis, which resulted in substantial regression of the mass. In patients with known Fahr’s disease, new-onset headaches and related symptoms should warrant evaluation for possible brain tumors. In these cases, imaging findings should be assessed along with physical examination findings and the patient’s medical history to support the diagnostic process.
dc.identifier.citationTaydaş, O., Has, B., Sakçı, Z., Oğul, H. ve Kantarcı, M. (2025). Solitary metastasis mimicking glioblastoma in a patient with fahr’s disease. Indian Journal of Surgical Oncology, 16(3), 807-812. http://dx.doi.org/10.1007/s13193-024-02137-z
dc.identifier.doi10.1007/s13193-024-02137-z
dc.identifier.endpage812
dc.identifier.issn0975-7651
dc.identifier.issn0976-6952
dc.identifier.issue3
dc.identifier.pmid40687874
dc.identifier.scopus2-s2.0-85210573153
dc.identifier.scopusqualityQ3
dc.identifier.startpage807
dc.identifier.urihttp://dx.doi.org/10.1007/s13193-024-02137-z
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13257
dc.identifier.volume16
dc.identifier.wosWOS:001366650000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOğul, Hayri
dc.institutionauthorid0000-0001-5989-3729
dc.language.isoen
dc.relation.ispartofIndian Journal of Surgical Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectFahr’s Disease
dc.subjectGlioblastoma
dc.subjectMagnetic Resonance Imaging
dc.subjectMetastasis
dc.titleSolitary metastasis mimicking glioblastoma in a patient with fahr’s disease
dc.typeArticle

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