The protective effects of different treatments on rat salivary glands after radiotherapy

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dc.contributor.authorKonak, Murat
dc.contributor.authorCıncık, Hakan
dc.contributor.authorErkul, Evren
dc.contributor.authorKüçükodacı, Zafer
dc.contributor.authorGüngör, Atila
dc.contributor.authorÖzdemir, Sevim
dc.contributor.authorÇekin, Engin
dc.contributor.authorArisan, Volkan
dc.contributor.authorMutluoğlu, Mesut
dc.contributor.authorSalihoğlu, Murat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:17Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:17Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000387700400056
dc.descriptionPubMed ID: 27324888
dc.description.abstractThis study was aimed to evaluate the efficacy of treatment modalities for minimizing salivary gland damage caused by radiotherapy. Forty rats were divided into five groups. Group 1 had no irradiation or any treatment. Group 2 underwent only 15 Gy single dose radiotherapy. N-acetylcysteine, dexamethasone, hyperbaric oxygen treatment were given, respectively to the group 3, 4 and 5 for 5 days. 15 Gy single dose radiotherapy was applied to the group 3, 4 and 5 on the second day. Pyknosis, lysis, and vacuolization were examined in ductal cells and pyknosis, lysis, vacuolization, inflammation and collective duct damage in acinar cells. Dexamethasone and hyperbaric oxygen did not prove to have a positive effect on acinar and ductal cell. N-acetylcysteine-applied group had statistically significantly lower amount of damage. We determined that the decrease of ductal and acinar cell damage in parotid glands of N-acetylcysteine-applied rats was more distinct and statistically.
dc.identifier.citationKonak, M., Cıncık, H., Erkul, E., Küçükodacı, Z., Güngör, A., Özdemir, S. ... Salihoğlu, M. (2016). The protective effects of different treatments on rat salivary glands after radiotherapy. European Archives Of Oto-Rhino-Laryngology, 273(12), 4501-4506. https://dx.doi.org/10.1007/s00405-016-4159-2
dc.identifier.doi10.1007/s00405-016-4159-2
dc.identifier.endpage4506
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue12
dc.identifier.scopusqualityQ1
dc.identifier.startpage4501
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-016-4159-2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2375
dc.identifier.volume273
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRadiotherapy
dc.subjectSalivary Glands
dc.subjectN-Acetylcysteine
dc.subjectHyperbaric Oxygen
dc.subjectCorticosteroid
dc.titleThe protective effects of different treatments on rat salivary glands after radiotherapy
dc.typeArticle

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