Systemic factors affecting human beta-defensins in oral cavity

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dc.authorid0000-0001-7986-7085
dc.contributor.authorAtalay, Nur
dc.contributor.authorBalcı, Nur
dc.contributor.authorGürsoy, Mervi
dc.contributor.authorGürsoy, Ulvi Kahraman
dc.date.accessioned2025-03-11T07:19:20Z
dc.date.available2025-03-11T07:19:20Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractHuman beta-defensins are host defense peptides with broad antimicrobial and inflammatory functions. In the oral cavity, these peptides are produced mainly by the keratinocytes of the epithelium; however, fibroblasts, monocytes, and macrophages also contribute to oral human beta-defensin expressions. The resident and immune cells of the oral cavity come into contact with various microbe-associated molecular patterns continuously and simultaneously. The overall antimicrobial cellular response is highly influenced by local and environmental factors. Recent studies have produced evidence showing that not only systemic chronic diseases but also systemic factors like hyperglycemia, pregnancy, the long-term use of certain vitamins, and aging can modulate oral cellular antimicrobial responses against microbial challenges. Therefore, the aim of this narrative review is to discuss the role of systemic factors on oral human beta-defensin expressions.
dc.description.sponsorshipFinnish Dental Society Apollonia ; Finnish Dental Society ; Minerva Foundation (Finland)
dc.identifier.citationAtalay, N., Balcı, N., Gürsoy, M. ve Gürsoy, U. K. (2024). Systemic factors affecting human beta-defensins in oral cavity. Pathogens, 13(8). http://dx.doi.org/10.3390/pathogens13080654
dc.identifier.doi10.3390/pathogens13080654
dc.identifier.issn2076-0817
dc.identifier.issue8
dc.identifier.pmid39204254
dc.identifier.scopus2-s2.0-85202464524
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.3390/pathogens13080654
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12900
dc.identifier.volume13
dc.identifier.wosWOS:001305098800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBalcı, Nur
dc.institutionauthorid0000-0001-7986-7085
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofPathogens
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAging
dc.subjectDefensins
dc.subjectHyperglycemia
dc.subjectPeriodontal Diseases
dc.subjectPeriodontium
dc.subjectPregnancy
dc.subjectRetinoids
dc.subjectVitamin D
dc.titleSystemic factors affecting human beta-defensins in oral cavity
dc.typeOther

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