The effect of omentectomy on the blood levels of adipokines in obese patients with endometrial cancer

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dc.contributor.authorComba, Cihan
dc.contributor.authorÖzdemir, İsa Aykut
dc.contributor.authorDemirayak, Gökhan
dc.contributor.authorErdoğan, Şakir Volkan
dc.contributor.authorDemir, Ömer
dc.contributor.authorYıldız, Güneş Özlem
dc.contributor.authorBulut, Huri
dc.contributor.authorKarakaş, Sema
dc.contributor.authorGülseren, Varol
dc.contributor.authorAfşar, Selim
dc.contributor.authorGüngördük, Kemal
dc.date.accessioned2022-07-04T05:41:04Z
dc.date.available2022-07-04T05:41:04Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractObjective: To investigate the blood levels of adipokines in obese patients with endometrial cancer who have and have not undergone omentectomy. Methods: Between September 2017 and September 2019, the study recruited 54 patients with endometrial cancer. Measurements were taken of blood levels of human leptin, perilipin-1, adiponectin, adipolin, resistin, visfatin, and estrone preoperatively and postoperatively before adjuvant therapy or at the end of one month. The serum samples were separated by centrifugation for 10 mins at 3,000 revolutions/min, then stored at ?80 °C until assay. Results: In this prospective study, a total of 54 endometrial cancer patients were analyzed in two separate groups according to the omentectomy status. Comprehensive staging surgery with omentectomy and without omentectomy was performed in 26 patients and 28 patients, respectively. The age, body mass index, body fat index, waist circumference, and skin thickness values of the patients with and without omentectomy were found to be similar. No statistically significant difference was determined between the patients with and without omentectomy in respect of the blood level of the adipokines measured preoperatively. A strong statistically significant correlation was determined between the pre and postoperative levels of Human Leptin (p = 0.002), perilipin-1(p = 0.001), adipolin (p < 0.001), adiponectin (p < 0.001), resistin (p = 0.001), visfatin (p < 0.001), and estrone (p = 0.004) (r = ?0.43, ?0.47, 0.75, 0.84, ?0.47, - 0.58, ?0.41, respectively) Conclusions: Omentectomy affected the postoperative blood levels of adipokines in obese patients with endometrial cancer. As omentectomy may have some positive effects on metabolism in these patients, it may be considered during endometrial cancer surgery due to the possible positive metabolic effects.
dc.identifier.citationComba, C., Özdemir, İ. A., Demirayak, G., Erdoğan, Ş. V., Demir, Ö., Yıldız, G. Ö. ... Güngördük, K. (2022). The effect of omentectomy on the blood levels of adipokines in obese patients with endometrial cancer. Obesity Research and Clinical Practice, 16(3), 242-248. http://doi.org/10.1016/j.orcp.2022.06.002
dc.identifier.doi10.1016/j.orcp.2022.06.002
dc.identifier.endpage248
dc.identifier.issn1871-403X
dc.identifier.issue3
dc.identifier.pmid35701296
dc.identifier.scopus2-s2.0-85132220540
dc.identifier.scopusqualityQ2
dc.identifier.startpage242
dc.identifier.urihttp://doi.org/10.1016/j.orcp.2022.06.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9554
dc.identifier.volume16
dc.identifier.wos000816207800008en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzdemir, İsa Aykut
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofObesity Research and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAdipolin
dc.subjectAdiponectin
dc.subjectEndometrial Cancer
dc.subjectLeptin
dc.subjectOmentectomy
dc.subjectPerilipin-1
dc.subjectResistin
dc.subjectVisfatin
dc.titleThe effect of omentectomy on the blood levels of adipokines in obese patients with endometrial cancer
dc.typeArticle

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