Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice

Basit Öğe Kaydı
dc.authorid0000-0002-5072-132X
dc.authorid0000-0001-6494-8923
dc.authorid0000-0002-9013-2298
dc.authorid0000-0002-4051-2559
dc.authorid0000-0001-7702-2441
dc.authorid0000-0002-9704-6173
dc.contributor.authorÇağlayan, Berrak
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorDalay, Arman
dc.contributor.authorAltunay, Serdar
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorErten, Füsun
dc.contributor.authorOrhan, Cemal
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorYuluğ, Burak
dc.contributor.authorJuturu, Vijaya
dc.contributor.authorŞahin, Kazım
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:42Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.descriptionWOS: 000462022300026
dc.descriptionPubMed ID: 30406889
dc.description.abstractTraumatic brain injury (TBI) is the leading cause of mortality and morbidity in young adults and children in the industrialized countries; however, there are presently no FDA approved therapies. TBI results in oxidative stress due to the overproduction of reactive oxygen species and overwhelming of the endogenous antioxidant mechanisms. Recently, it has been reported that antioxidants including phytochemicals have a protective role against oxidative damage and inflammation after TBI. To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappa B) signaling pathways in TBI, a cryogenic injury model was induced in mice. Here, we showed that AITC administered immediately after the injury significantly decreased infarct volume and blood-brain barrier (BBB) permeability. Protein levels of proinflammatory cytokines interleukin-1 beta (IL1 beta) and interleukin-6 (IL6), glial fibrillary acidic protein (GFAP) and NF-kappa B were decreased, while Nrf2, growth-associated protein 43 (GAP43) and neural cell adhesion molecule levels were increased with AITC when compared with vehicle control. Our results demonstrated that the antioxidant molecule AITC, when applied immediately after TBI, provided beneficial effects on inflammatory processes while improving infarct volume and BBB permeability. Increased levels of plasticity markers, as well as an antioxidant gene regulator, Nrf2, by AITC, suggest that future studies are warranted to assess the protective activities of dietary or medicinal AITC in clinical studies.
dc.description.sponsorshipOmniActive Health Technologies Inc.; Turkish Academy of Sciencesen_US
dc.description.sponsorshipThis study was supported by OmniActive Health Technologies Inc. (NJ, USA). This work was also supported in part by the Turkish Academy of Sciences.en_US
dc.identifier.citationÇağlayan, B., Kılıç, E., Dalay, A., Altunay, S., Tuzcu, M., Erten, F. … Şahin, K. (2019). Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice. Molecular Biology Reports, 46(1), 241-250. https://dx.doi.org/10.1007/s11033-018-4465-4
dc.identifier.doi10.1007/s11033-018-4465-4
dc.identifier.endpage250
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage241
dc.identifier.urihttps://dx.doi.org/10.1007/s11033-018-4465-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1725
dc.identifier.volume46
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectTraumatic Brain Injury
dc.subjectAllyl Isothiocyanate
dc.subjectNF-Kappa B
dc.subjectNrf2
dc.titleAllyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Çaǧlayan, Berrak.pdf
Boyut:
1.42 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu