Central macular thickness in diabetic macular edema

Güngel, H.; Aral, H.; Erdenen, F.; Gökçe, M.; Karaman Erdur, Sevil

Central macular thickness in diabetic macular edema

dc.authorid	0000-0001-9829-7268
dc.contributor.author	Güngel, H.
dc.contributor.author	Aral, H.
dc.contributor.author	Erdenen, F.
dc.contributor.author	Gökçe, M.
dc.contributor.author	Karaman Erdur, Sevil
dc.date.accessioned	2021-06-24T11:55:45Z
dc.date.available	2021-06-24T11:55:45Z
dc.date.issued	2020
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstract	Context. Retinal microvascular dysfunction differs in macular edema lesions in the two eyes of the same patient with diabetic retinopathy. Objective. To evaluate the relationship between central macular thickness (CMT) and metabolic/systemic factors including anthropometric and laboratory findings, in patients with regressed diabetic retinopathy and a history of pars plana vitrectomy (PPV) combined with internal limiting membrane peeling in one eye. Subjects and Methods. Forty-two eyes with PPV and the same patients' fellow 42 eyes (without PPV) included this study. Fasting blood samples of these 42 diabetics were collected to study adiponectin levels and other routine parameters. Results. The average hemoglobinA lc value was 7.3 +/- 1.3%. CMT of the vitrectomized eyes were significantly correlated with atherogenic index of plasma, total cholesterol, low density lipoprotein cholesterol and uric acid (UA). On the other hand, CMT of the nonvitrectomized fellow eyes signifi cantly correlated with glucose levels and diabetes duration. Adiponectin, adiponectin/body mass index, adiponectin/fibrinogen were found significantly higher in the subgroup with CMT >= 300 mu m in the vitrectomized eyes (P<0.05). UA levels were higher in the subgroup with CMT >= 300 mu m in the fellow (nonvitrectomized) eyes (P<0.05). Conclusions. Although there was no relationship between CMT and hemoglobinA1c values, CMT seemed to be affected by atherogenicity, prooxidant chemical alterations in the course of inflammation, so determination of adiponectin and UA levels may be suggested before surgery to predict the atherosclerotic damage and the postoperative CMT value. Vitrectomy performed at the proper time may be helpful in metabolic remodeling process of the retinal tissue along with life style changes, well control of diabetes, and intraocular treatments.
dc.identifier.citation	Güngel, H., Aral, H., Erdenen, F., Gökçe, M. ve Karaman Erdur, S. (2020). Central macular thickness in diabetic macular edema. Acta Endocrinologica, 16(4), 417-425. https://dx.doi.org/10.4183/aeb.2020.417
dc.identifier.doi	10.4183/aeb.2020.417
dc.identifier.endpage	425
dc.identifier.issn	1841-0987
dc.identifier.issn	1843-066X
dc.identifier.issue	4
dc.identifier.scopusquality	Q3
dc.identifier.startpage	417
dc.identifier.uri	https://dx.doi.org/10.4183/aeb.2020.417
dc.identifier.uri	https://hdl.handle.net/20.500.12511/7305
dc.identifier.volume	16
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.language.iso	en
dc.publisher	Acta Endocrinologica Foundation
dc.relation.ispartof	Acta Endocrinologica	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Adiponectin
dc.subject	Uric Acid
dc.subject	Diabetic Retinopathy
dc.subject	Metabolism
dc.subject	Central Macular Thickness
dc.title	Central macular thickness in diabetic macular edema
dc.type	Article