A proposal for the etiopathogenesis of acquired cold urticaria: Role of substance p, angiotensin-converting enzyme and mast cell chymase

Basit Öğe Kaydı
dc.authorid0000-0002-2049-1316
dc.contributor.authorÇaytemel, Ceyda
dc.contributor.authorTürko?lu, Zafer
dc.contributor.authorA?ırgöl, Şenay
dc.contributor.authorUstao?lu, Eda
dc.contributor.authorTopaloğlu Demir, Filiz
dc.contributor.authorUzuner, Esen
dc.date.accessioned2022-08-12T11:51:55Z
dc.date.available2022-08-12T11:51:55Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.description.abstractBackground: The etiopathogenesis and cold stimulation mechanism are not fully understood in cold urticaria (CU). Substance P (SP) is released from skin neurons as a result of cold stimulation. It causes mast cell degranulation and therefore causes mast cell chymase (MCC) release. Angiotensin-converting enzyme (ACE) plays a role in removing SP from the environment. ACE also catalyses the conversion of angiotensin I (AT1) to angiotensin II (AT2), like MCC. This study aims to investigate the role of SP, ACE and MCC in the pathogenesis of CU. Methods: Patients with acquired CU were included in the study. Two punch biopsies were taken from the urticaria plaque resulting from the stimulation and the intact skin without lesions. The samples were evaluated histopathologically. All samples were stained immunohistochemically with SP, ACE and MCC antibodies. Results: The number of patients included in the study was 21. In the plaque lesion, the presence of dermal neutrophil and eosinophil, neutrophil in the vascular lumen were found to be statistically significantly higher than intact tissue (p = 0.046, P = 0.014, P = 0.014). Strong positive staining was detected in the full thickness of the epidermis, vascular endothelial cells, eccrine and sebaceous glands with ACE. MCC was statistically significantly higher in lesional skin than lesion-free skin samples (p < 0.001). Conclusions: Mast cell maintains its central role in CU pathogenesis. SP, which causes neurogenic inflammation, may not be detected due to its rapid destruction in the tissue. Strong staining of ACE, which takes part in the local renin-Angiotensin-Aldosterone (RAS) system in the skin, should be documented quantitatively.
dc.description.sponsorshipTurkish Society of Dermatologyen_US
dc.identifier.citationÇaytemel, C., Türko?lu, Z., A?ırgöl, Ş., Ustao?lu, E., Topaloğlu Demir, F. ve Uzuner, E. (2022). A proposal for the etiopathogenesis of acquired cold urticaria: Role of substance p, angiotensin-converting enzyme and mast cell chymase. Indian Journal of Dermatology, 67(2), 205-205. http://doi.org/10.4103/ijd.ijd_694_21
dc.identifier.doi10.4103/ijd.ijd_694_21
dc.identifier.endpage205
dc.identifier.issn0019-5154
dc.identifier.issn1998-3611
dc.identifier.issue2
dc.identifier.pmid36092209
dc.identifier.scopus2-s2.0-85135114124
dc.identifier.scopusqualityQ3
dc.identifier.startpage205
dc.identifier.urihttp://doi.org/10.4103/ijd.ijd_694_21
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9650
dc.identifier.volume67
dc.identifier.wos000838720600038en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTopaloğlu Demir, Filiz
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAngiotensin-Converting Enzyme
dc.subjectChymase
dc.subjectCold Urticaria
dc.subjectInducible Urticaria
dc.subjectMast Cell
dc.subjectSubstance P
dc.titleA proposal for the etiopathogenesis of acquired cold urticaria: Role of substance p, angiotensin-converting enzyme and mast cell chymase
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu