YKL-40, soluble IL-2 receptor, angiotensin converting enzyme and C-reactive protein: Comparison of markers of sarcoidosis activity

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dc.authorid0000-0001-6639-2797
dc.contributor.authorUysal, Pelin
dc.contributor.authorDurmuş, Sinem
dc.contributor.authorSözer, Volkan
dc.contributor.authorGelişgen, Remise
dc.contributor.authorSeyhan, Ekrem Cengiz
dc.contributor.authorErdenen, Füsun
dc.contributor.authorŞimşek, Gönül
dc.contributor.authorUzun, Hafize
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:13Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:13Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000448394900042
dc.descriptionPubMed ID: 30154391
dc.description.abstractThe aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients and to analyse chitinase-3-like protein 1 (YKL-40), soluble interleukin-2 receptor (sIL-2R), neopterin concentrations and adenosine deaminase (ADA) activity in serum of these patients in order to understand their potential as disease markers. Fifty-nine patients affected by chronic sarcoidosis, in active (20 patients) and inactive (39 patients) phase according to the clinical, radiological and laboratory criteria were studied. Serum YKL-40, sIL-2R, high-sensitive C-reactive protein (hs-CRP), neopterin levels and ADA activities were evaluated and compared with those of 25 healthy controls. Individuals with chronic sarcoidosis were significantly higher serum YKL-40, sIL-2R, neopterin, hs-CRP concentrations, angiotensin converting enzyme (ACE) and ADA activity than those of control subjects. Sarcoidosis patients in the active phase of the disease were significantly higher YKL-40, sIL-2R, hs-CRP levels and ACE activity than those in the inactive phase, while ADA activities and neopterin levels did not display any significant difference between the active and inactive disease groups. In comparison to the other parameters, as panel measurement of the serum YKL-40, sIL-2R, ACE and hs-CRP indicate a greater discrimination between active and inactive disease. The results indicate that serum YKL-40, sIL-2R, ACE and hs-CRP concentrations may be useful marker for monitoring sarcoidosis disease activity.
dc.identifier.citationUysal, P., Durmuş, S., Sözer, V., Gelişgen, R., Seyhan, E., Erdenen, F. ... Uzun, H. (2018). YKL-40, soluble IL-2 receptor, angiotensin converting enzyme and C-reactive protein: Comparison of markers of sarcoidosis activity. Biomolecules, 8(3). https://dx.doi.org/10.3390/biom8030084
dc.identifier.doi10.3390/biom8030084
dc.identifier.issn2218-273X
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3390/biom8030084
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1919
dc.identifier.volume8
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofBiomoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSarcoidosis
dc.subjectChitinase 3 Like Protein 1 (YKL-40)
dc.subjectSoluble Interleukin 2 Receptor (sIL-2R)
dc.subjectHigh Sensitive C-Reactive Protein (hs-CRP)
dc.subjectAdenosine Deaminase (ADA)
dc.subjectAngiotensin Converting Enzyme (ACE)
dc.subjectNeopterin (NEO)
dc.titleYKL-40, soluble IL-2 receptor, angiotensin converting enzyme and C-reactive protein: Comparison of markers of sarcoidosis activity
dc.typeArticle

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