Parkinson’s disease alters the composition of subgingival microbiome

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dc.authorid0000-0001-7409-1484
dc.authorid0000-0001-7986-7085
dc.authorid0000-0002-7712-738X
dc.authorid0000-0002-8811-2263
dc.contributor.authorYay, Ekin
dc.contributor.authorYılmaz, Melis
dc.contributor.authorToygar, Hilal
dc.contributor.authorBalcı, Nur
dc.contributor.authorAlvarez Rivas, Carla
dc.contributor.authorBolluk Kılıç, Başak
dc.contributor.authorZırh, Ali
dc.contributor.authorPaster, Bruce
dc.contributor.authorKantarcı, Alpdoğan
dc.date.accessioned2023-09-12T10:44:11Z
dc.date.available2023-09-12T10:44:11Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractAim: The current study aimed to test the hypothesis that Parkinson’s disease exacerbates periodontitis by altering its microbiome. Materials and Methods: Clinical periodontal parameters were recorded. Subgingival samples from healthy controls, periodontitis patients (PD), and Parkinson’s patients with periodontitis (PA+PD) were analyzed using the checkerboard DNA-DNA hybridization technique for targeting 40 bacterial species typically associated with periodontal disease and health. Next-generation sequencing (NGS) of the 16S ribosomal RNA gene (V1-V3 regions) was performed to analyze the microbiome comprehensively. Results: Parkinson’s patients had mild-to-moderate motor dysfunctions. Bleeding on probing was significantly increased in the PA+PD group compared to PD (p < 0.05). With checkerboard analysis, PA was associated with increased Treponema socranskii (p = 0.0062), Peptostreptococcaceae_[G-6] [Eubacterium]_nodatum (p = 0.0439), Parvimona micra (p < 0.0001), Prevotella melaninogenica (p = 0.0002), Lachnoanaerobaculum saburreum (p < 0.0001), and Streptococcus anginosus (p = 0.0020). Streptococcus intermedia (p = 0.0042), P.nodatum (p = 0.0022), P.micra (p = 0.0002), Treponema denticola (p = 0.0045), L.saburreum (p = 0.0267), P.melaninogenica (p = 0.0017), Campylobacter rectus (p = 0.0020), and T.socranskii (p = 0.0002) were higher; Aggregatibacter actinomycetemcomitans (p = 0.0072) was lower in deep pockets in the PA+PD compared to PD. Schaalia odontolytica (p = 0.0351) and A.actinomycetemcomitans (p = 0.002) were lower; C.rectus (p = 0.0002), P.micra (p = 0065), Streptococcus constellatus (p = 0.0151), T.denticola (p = 0.0141), P.melaninogenica (p = 0.0057), and T.socranskii (p = 0.0316) were higher in shallow pockets in the PA+PD. Diversity decreased in PD (p = 0.001) and PA+PD (p = 0.026) compared to control, with minimal differences in alpha and beta diversities among PD and PA+PD based on NGS results. Conclusion: These data demonstrated that Parkinson’s disease modifies PD-associated subgingival microbiome.
dc.description.sponsorshipNational Institutes of Health ; National Institute on Agingen_US
dc.identifier.citationYay, E., Yılmaz, M., Toygar, H., Balcı, N., Alvarez Rivas, C., Bolluk Kılıç, B. ... Kantarcı, A. (2023). Parkinson’s disease alters the composition of subgingival microbiome. Journal of Oral Microbiology, 15(1). https://dx.doi.org/10.1080/20002297.2023.2250650
dc.identifier.doi10.1080/20002297.2023.2250650
dc.identifier.issn2000-2297
dc.identifier.issue1
dc.identifier.pmid37649970
dc.identifier.scopus2-s2.0-85169307809
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1080/20002297.2023.2250650
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11414
dc.identifier.volume15
dc.identifier.wos001056897300001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Melis
dc.institutionauthorToygar, Hilal
dc.institutionauthorBalcı, Nur
dc.institutionauthorBolluk Kılıç, Başak
dc.institutionauthorZırh, Ali
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofJournal of Oral Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectCheckerboard
dc.subjectMicrobiome
dc.subjectMicrobiota
dc.subjectParkinson’s Disease
dc.subjectPathogenesis
dc.subjectPeriodontitis
dc.titleParkinson’s disease alters the composition of subgingival microbiome
dc.typeArticle

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