Where we are in treat to target era? Predictive factors for remission and drug switching in patients with axial spondyloarthritis: A real-life evidence from BioStaR nationwide registry

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dc.authorid0000-0002-5852-3854
dc.contributor.authorBodur, Hatice
dc.contributor.authorYurdakul, Fatma Gül
dc.contributor.authorAtaman, Şebnem
dc.contributor.authorÇay, Hasan Fatih
dc.contributor.authorGürer, Gülcan
dc.contributor.authorÇapkın, Erhan
dc.contributor.authorSezer, İlhan
dc.contributor.authorDuruöz, Mehmet Tuncay
dc.contributor.authorAlkan Melikoğlu, Meltem
dc.contributor.authorRezvani, Aylin
dc.contributor.authorYağcı, İlker
dc.contributor.authorGöğüs, Feride
dc.contributor.authorKamanlı, Ayhan
dc.contributor.authorAkgül, Özgür
dc.contributor.authorÇevik, Remzi
dc.date.accessioned2022-12-12T12:17:14Z
dc.date.available2022-12-12T12:17:14Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.description.abstractObjectives Factors associated with disease activity of axial spondyloarthritis (axSpA) and switching of biologic disease-modifying anti-rheumatic drugs have not been clearly defined. We aimed to evaluate clinical characteristics of patients with axSpA, factors related to remission in treat to target era and predictive factors for biologic disease-modifying anti-rheumatic drug switching. Method A multicenter, observational cross-sectional study was performed between February 2019 and August 2019. We included all consecutive patients >= 18 years with axSpA. Demographic and clinical variables were prospectively recorded. Clinical tools included Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Metrology Index (BASMI), and Maastricht Ankylosing Spondylitis Enthesitis Score (MASES). Results There were 969 patients with a mean age of 43.4 +/- 10.8 years. There were 143 patients (14.8%) with remission and 223 (23.1%) patients with low disease activity. Male sex (p = 0.021), positive family history (p = 0.036), and human leukocyte antigen-B27 (p = 0.011) were predictors of remission by ASDAS-CRP. There were 654 patients (67.5%) who did not switch to another drug. The highest BASMI and MASES scores were calculated in patients with very high disease activity (p < 0.05). In patients with drug switching, the disease duration was significantly higher (p < 0.001) and the age at diagnosis was significantly lower (p = 0.016). There were significantly more patients with uveitis and higher scores of MASES and BASMI in patients who switch to another biologic disease-modifying anti-rheumatic drugs (p = 0 .003, p = 0 .009, and p = 0.004, respectively). Conclusions In patients with axSpA, male sex, younger age, and HLA-B27 positivity are associated with remission, while longer disease duration and accompanied uveitis appear to be related with drug switching.
dc.identifier.citationBodur, H., Yurdakul, F. G., Ataman, Ş., Çay, H. F., Gürer, G., Çapkın, E. ... Çevik, R. (2022). Where we are in treat to target era? Predictive factors for remission and drug switching in patients with axial spondyloarthritis: A real-life evidence from BioStaR nationwide registry. Clinical Rheumatology, 41(7), 2053-2063. https://doi.org/10.1007/s10067-022-06145-8
dc.identifier.doi10.1007/s10067-022-06145-8
dc.identifier.endpage2063
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue7
dc.identifier.pmid35353263
dc.identifier.scopus2-s2.0-85127446841
dc.identifier.scopusqualityQ1
dc.identifier.startpage2053
dc.identifier.urihttps://doi.org/10.1007/s10067-022-06145-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10112
dc.identifier.volume41
dc.identifier.wos000775708600001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorRezvani, Aylin
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDisease-Modifying Anti-Rheumatic Drugs
dc.subjectDrug Switching
dc.subjectRemission Induction
dc.subjectSpondyloarthritis
dc.titleWhere we are in treat to target era? Predictive factors for remission and drug switching in patients with axial spondyloarthritis: A real-life evidence from BioStaR nationwide registry
dc.typeArticle

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