Association of vitamin D deficiency with arterial stiffness in newly diagnosed hypertension

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dc.authorid0000-0003-0230-6575
dc.authorid0000-0002-4281-0867
dc.contributor.authorÇakal, Sinem Deniz
dc.contributor.authorÇakal, Beytullah
dc.contributor.authorKaraca, O?uz
dc.date.accessioned2021-03-26T06:45:42Z
dc.date.available2021-03-26T06:45:42Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Vitamin D has beneficial effects on vascular endothelial function, blood pressure (BP) and arterial stiffness. Arterial stiffness increases in early-stage hypertensive patients and it is a strong predictor of cardiovascular morbidity and mortality. The purpose of this study was to assess the association between serum 25-hydroxyvitamin D (25-OH D) levels and arterial stiffness in patients with newly diagnosed hypertension. METHOD: Our study included 100 newly diagnosed hypertensive patients (63 male, 37 female and mean age: 51.7 ± 10.3 years) without cardiovascular disease, malignancy, chronic kidney disease and diabetes mellitus. Patients were divided into two groups: vitamin D deficiency group (<20 ng/ml) and normal vitamin D group (?20 ng/ml). Twenty-four-hour, daytime and nighttime ambulatory BP readings were recorded. Mobil-O-Graph ARC solver algorithm was used to evaluate arterial stiffness parameters of pulse wave velocity (PWV) (m/s), augmentation index normalized with 75/min heart rate (Alx@75). RESULTS: Patients with vitamin D deficency had higher values of Alx@75 and PWV values (20.9 ± 9 vs. 16.8 ± 6.9, P = 0.018 and 8.37 ± 1.16 vs. 6.9 ± 0.9, P = 0.001, respectively) despite similar 24-hour ambulatory BP monitoring in both groups. Level of serum calcium was significantly higher in vitamin D deficiency group (9.5 ± 0.23 vs. 9.3 ± 0.12, P = 0.007). Nighttime SBP was higher in vitamin D deficiency group (133.2 ± 14.3 mmHg vs. 126.3 ± 17.2 mmHg; P = 0.03) and also, vitamin D deficiency group had non-dipping SBP pattern compared to normal Vitamin D group (P = 0.013). CONCLUSION: Vitamin D deficiency is associated with increased arterial stiffness in newly diagnosed hypertensive patients in terms of increased PWV and Alx@75 values.
dc.identifier.citationÇakal, S. D., Çakal, B. ve Karaca, O. (2021). Association of vitamin D deficiency with arterial stiffness in newly diagnosed hypertension. Blood Pressure Monitoring, 26(2), 113-117. https://dx.doi.org/10.1097/MBP.0000000000000497
dc.identifier.doi10.1097/MBP.0000000000000497
dc.identifier.endpage117
dc.identifier.issn1473-5725
dc.identifier.issn1359-5237
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage113
dc.identifier.urihttps://dx.doi.org/10.1097/MBP.0000000000000497
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6654
dc.identifier.volume26
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofBlood Pressure Monitoringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectArterial Stiffness
dc.subjectAugmentation Index
dc.subjectBlood Pressure
dc.subjectHypertension
dc.subjectPulse Wave Velocity
dc.subjectVitamin D
dc.titleAssociation of vitamin D deficiency with arterial stiffness in newly diagnosed hypertension
dc.typeArticle

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