Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty

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dc.authorid0000-0003-4930-8447
dc.contributor.authorÇetinkaya, Semra
dc.contributor.authorPoyrazoğlu, Şükran
dc.contributor.authorBaş, Firdevs
dc.contributor.authorErcan, Oya
dc.contributor.authorYıldız, Metin
dc.contributor.authorAdal, Erdal
dc.contributor.authorBereket, Abdullah
dc.contributor.authorAbalı, Saygın
dc.contributor.authorAycan, Zehra
dc.contributor.authorErdeve, Senay Savaş
dc.contributor.authorBerberoğlu, Merih
dc.contributor.authorŞıklar, Zeynep
dc.contributor.authorTayfun, Meltem
dc.contributor.authorDarcan, Şükran
dc.contributor.authorMengen, Eda
dc.contributor.authorBircan, İffet
dc.contributor.authorJones, Filiz Mine Çizmecioğlu
dc.contributor.authorŞimşek, Enver
dc.contributor.authorPapatya, Esra Deniz
dc.contributor.authorÖzbek, Mehmet Nuri
dc.contributor.authorBolu, Semih
dc.contributor.authorAbacı, Ayhan
dc.contributor.authorBüyükinan, Muammer
dc.contributor.authorDarendeliler, Feyza
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:26Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:26Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000423677900009
dc.descriptionPubMed ID: 29353264
dc.description.abstractBackground: The aim of the study was to assess the response to growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting growth response were assessed (especially mini-puberty). Methods: Medical reports of GHD patients in whom treatment was initiated between 0 and 3 years of age were retrospectively evaluated. Results: The cohort numbered 67. The diagnosis age was 12.4 +/- 8.6 months, peak GH stimulation test response (at diagnosis) as 1.0 +/- 1.4 ng/mL. The first and second years length gain was 15.0 +/- 4.3 and 10.4 +/- 3.4 cm. Weight gain had the largest effect on first year growth response; whereas weight gain and GH dose were both important factors affecting second year growth response. In the multiple pituitary hormone deficiency (MPHD) group (n = 50), first year GH response was significantly greater than in the isolated GH deficiency (IGHD) group (n = 17) (p = 0.030). In addition first year growth response of infants starting GH between 0 and 12 months of age (n = 24) was significantly greater than those who started treatment between 12 and 36 months of age (n = 43) (p <0.001). These differences were not seen in the second year. Delta Length/height standard deviation score (SDS), Delta body weight SDS, length/height SDS, weight SDS in MPHD without hypogonadism for the first year of the GH treatment were found as significantly better than MPHD with hypogonadism. Conclusions: Early onsets of GH treatment, good weight gain in the first year of the treatment and good weight gain-GH dose in the second year of the treatment are the factors that have the greatest effect on length gain in early onset GHD. The presence of the sex steroid hormones during minipubertal period influence growth pattern positively under GH treatment (closer to the normal percentage according to age and gender).
dc.description.sponsorshipTurkish Pediatric Endocrinology and Diabetes Society [022014]en_US
dc.description.sponsorshipThis work was supported by the Turkish Pediatric Endocrinology and Diabetes Society (Grant Number: 022014).en_US
dc.identifier.citationÇetinkaya, S., Poyrazoğlu, Ş., Baş, F., Ercan, O., Yıldız, M., Adal, E. ... Darendeliler, F. (2018). Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty. Journal of Pediatric Endocrinology & Metabolism, 31(2), 175-184. https://dx.doi.org/10.1515/jpem-2017-0123
dc.identifier.doi10.1515/jpem-2017-0123
dc.identifier.endpage184
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage175
dc.identifier.urihttps://dx.doi.org/10.1515/jpem-2017-0123
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3269
dc.identifier.volume31
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter de Gruyter Gmbh
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGrowth Hormone Deficiency
dc.subjectGrowth Hormone Treatment
dc.subjectGrowth Response
dc.subjectInfancy
dc.subjectMini Puberty
dc.titleResponse to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty
dc.typeArticle

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