Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress

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dc.authorid0000-0002-2306-5937
dc.authorid0000-0003-4292-5717
dc.authorid0000-0001-5118-4776
dc.authorid0000-0003-4856-9987
dc.authorid0000-0001-5688-136X
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorToprak, Güven
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorBektay, Muhammed Yunus
dc.contributor.authorMutlu Burnaz, Özlem
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2021-05-27T11:09:25Z
dc.date.available2021-05-27T11:09:25Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractRepetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify Brain-Derived Neurotrophic Factor (BDNF) and oxidative stress levels in many neurological and psychiatric diseases, there is still no study evaluating the relationship between memory performance, BDNF, oxidative stress, and resting brain connectivity following rTMS in Alzheimer?s patients. Furthermore, there are increasing clinical data showing that the stimulation of strategic brain regions may lead to more robust improvements in memory functions compared to conventional rTMS. In this study, we aimed to evaluate the possible disease-modifying effects of rTMS on the lateral parietal cortex in AD patients who have the highest connectivity with the hippocampus. To fill the mentioned research gaps, we have evaluated the relationships between resting-state Functional Magnetic Resonance Imaging (fMRI), cognitive scores, blood BDNF levels, and total oxidative/antioxidant status to explain the therapeutic and potential disease-modifying effects of rTMS which has been applied at 20 Hz frequencies for two weeks. Our results showed significantly increased visual recognition memory functions and clock drawing test scores which were associated with elevated peripheral BDNF levels, and decreased oxidant status after two weeks of left lateral parietal TMS stimulation. Clinically our findings suggest that the left parietal region targeted rTMS application leads to significant improvement in familiarity-based cognition associated with the network connections between the left parietal region and the hippocampus.
dc.description.sponsorshipIstanbul Medipol University Research Fund ; Research Institute for Health and Technologies (SABITA), Regenerative and Restorative Medicine Research Center (REMER), functional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN)en_US
dc.identifier.citationVelioğlu, H. A., Hanoğlu, L., Bayraktaroğlu, Z., Toprak, G., Güler, E. M., Bektay, M. Y. ... Yuluğ, B. (2021). Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress. Neurobiology of Learning and Memory, 180. https://dx.doi.org/10.1016/j.nlm.2021.107410
dc.identifier.doi10.1016/j.nlm.2021.107410
dc.identifier.issn1074-7427
dc.identifier.issn1095-9564
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1016/j.nlm.2021.107410
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6951
dc.identifier.volume180
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.relation.ispartofNeurobiology of Learning and Memoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectrTMS
dc.subjectBDNF
dc.subjectImplicit Memory
dc.subjectOxidant Status
dc.subjectfMRI
dc.titleLeft lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress
dc.typeArticle

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