Therapeutic effects of vitamin D on acetic acid-induced colitis in rats
| dc.authorid | 0000-0001-9378-4438 | |
| dc.contributor.author | Bademci, Refik | |
| dc.contributor.author | Erdoğan, Mümin Alper | |
| dc.contributor.author | Kara, Ali Yücel | |
| dc.contributor.author | Yiğittürk, Gürkan | |
| dc.contributor.author | Erbaş, Oytun | |
| dc.date.accessioned | 2020-07-09T15:12:59Z | |
| dc.date.available | 2020-07-09T15:12:59Z | |
| dc.date.issued | 2020 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı | |
| dc.description.abstract | Purpose: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 mu g/kg for 5 days. Results: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p<0.000). Conclusion: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment. | |
| dc.identifier.citation | Bademci, R., Erdoğan, M. A., Kara, A. Y., Yiğittürk, G. ve Erbaş, O. (2020). Therapeutic effects of vitamin D on acetic acid-induced colitis in rats. Acta Cirurgica Brasileira, 35(4). http://dx.doi.org/10.1590/s0102-865020200040000004 | |
| dc.identifier.doi | 10.1590/s0102-865020200040000004 | |
| dc.identifier.issn | 0102-8650 | |
| dc.identifier.issn | 1678-2674 | |
| dc.identifier.issue | 4 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.uri | http://dx.doi.org/10.1590/s0102-865020200040000004 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/5443 | |
| dc.identifier.volume | 35 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Acta Cirurgica Brasileira | |
| dc.relation.ispartof | Acta Cirurgica Brasileira | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/deed.en | * |
| dc.subject | Calcitriol | |
| dc.subject | Colitis | |
| dc.subject | Tumor Necrosis Factor-Alpha | |
| dc.subject | Malondialdehyde | |
| dc.subject | Rats | |
| dc.title | Therapeutic effects of vitamin D on acetic acid-induced colitis in rats | |
| dc.type | Article |
