Evaluation of cardiac arrhythmias by electrocardiographic markers in pediatric patients who have tuberous sclerosis without cardiac rhabdomyoma

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dc.authorid0000-0002-3206-6851
dc.contributor.authorYozgat, Yasemin
dc.contributor.authorKuş, Hazar Doğuş
dc.contributor.authorKahraman, Fatma
dc.contributor.authorElagöz Yüksel, Mine
dc.contributor.authorFırat, Cem Koray
dc.contributor.authorToprak, Atakan
dc.contributor.authorYozgat, Can Yılmaz
dc.contributor.authorYakut, Kadriye
dc.contributor.authorSönmez Şahin, Şeyma
dc.contributor.authorİşcan, Akın
dc.contributor.authorOtçu Temur, Hafize
dc.contributor.authorErgör, Serap Nur
dc.contributor.authorErenberk, Ufuk
dc.contributor.authorSarıtaş, Tuba Berra
dc.date.accessioned2021-05-18T07:18:14Z
dc.date.available2021-05-18T07:18:14Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Tuberous sclerosis (TS) is an autosomal dominant and hereditary disorder. Cardiac rhabdomyoma and arrhythmias are the most deleterious risk factors linked to TS. Although arrhythmias in pediatric patients with TS who have cardiac rhabdomyoma have been frequently reported, arrhythmia in patients who have TS without rhabdomyoma is rarely reported in the literature. The study aimed to assess the susceptibility of pediatric patients who have TS without cardiac rhabdomyoma to cardiac arrhythmia using electrocardiographic (ECG) markers. Methods: This prospective study included 10 patients who had TS without cardiac rhabdomyoma. The control group was made up of 30 healthy children of the same age and sex as the patient group. P wave, P wave dispersion, QT dispersion, QTc dispersion, TP-e interval, and TP-e interval dispersion were calculated on 12-lead surface ECGs for each patient in both groups and compared. Results: P wave, P wave dispersion, QT dispersion, and QTc dispersion were found to be significantly higher in the patient group (P<0.001). Furthermore, patients had a greater Tp-e interval and Tp-e interval dispersion than healthy children (P<0.001). Conclusion: Pediatric patients with TS without cardiac rhabdomyoma might be prone to atrial and ventricular arrhythmias according to their prolonged ECG markers. Our findings suggest that patients with TS without cardiac rhabdomyoma need close monitoring for atrial and ventricular arrhythmias.
dc.identifier.citationYozgat, Y., Kuş, H. D., Kahraman, F., Elagöz Yüksel, M., Fırat, C. K., Toprak, A. ... Sarıtaş, T. B. (2021). Evaluation of cardiac arrhythmias by electrocardiographic markers in pediatric patients who have tuberous sclerosis without cardiac rhabdomyoma. Archives de Pediatrie, 28(3), 204-208. https://dx.doi.org/10.1016/j.arcped.2021.02.008
dc.identifier.doi10.1016/j.arcped.2021.02.008
dc.identifier.endpage208
dc.identifier.issn0929-693X
dc.identifier.issn1769-664X
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage204
dc.identifier.urihttps://dx.doi.org/10.1016/j.arcped.2021.02.008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6833
dc.identifier.volume28
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofArchives de Pediatrieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectTuberous Sclerosis
dc.subjectCardiac Rhabdomyoma
dc.subjectP Wave Dispersion
dc.subjectQTc Dispersion
dc.subjectTp-e Interval Dispersion
dc.titleEvaluation of cardiac arrhythmias by electrocardiographic markers in pediatric patients who have tuberous sclerosis without cardiac rhabdomyoma
dc.typeArticle

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