A comparative study on monomer elution and cytotoxicity of different adhesive restoration materials

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dc.contributor.authorToz, Tuğba
dc.contributor.authorKiremitçi, Arlin
dc.contributor.authorÇakmak, Anıl Sera
dc.contributor.authorÜnsal Tan, Oya
dc.contributor.authorPalaska, Erhan
dc.contributor.authorGümüşderelioğlu, Menemşe
dc.contributor.authorÖzcan, Mutlu
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:13Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:13Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi Ana Bilim Dalı
dc.descriptionWOS: 000387925700005
dc.description.abstractThis study evaluated monomer release and cytotoxicity of different adhesive restoration materials used for dental restorations. The extracts (1, 2, and 7days) of three types of adhesive dental restoration materials, [Quixfill (QF), Silorane Restorative (SR), and Ketac N 100 Restorative (KR)], and the adhesive resins, [XP Bond (XP), Silorane Primer (SP), Ketac N 100 Primer (KP), and Silorane Bond (SB)] were analyzed using high performance liquid chromatography/mass spectrometry (HPLC-MS). The cytotoxicity levels were determined at different time points (24, 48, and 72h) of cell culture using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) assay. All adhesive resin materials showed monomer release at varying amounts with the highest release after 7days. The lowest amount of release was observed in QF and the highest with KP. Bis-Phenol A (BPA) was not detected in SP and KR that contain bisphenol-A diglycidyl ether dimethacrylate (bis-GMA). Decamethylpenthasiloxane (D5) was not eluted from SR. Except for SR and QF, all other adhesive restoration materials showed different degrees of toxicity along with different monomer release kinetics. The correlation between the monomer release and cytotoxicity of the materials indicated that the cytotoxicity of the materials increased with the monomer release (Spearman's rho correlation coefficient - r). The correlation after 48h was statistically significant (r=-0.342, p=0.017).
dc.identifier.citationToz, T., Kiremitçi, A., Çakmak, A. S., Ünsal Tan, O., Palaska, E., Gümüşderelioğlu, M. ve Özcan, M. (2017). A comparative study on monomer elution and cytotoxicity of different adhesive restoration materials. Journal of Adhesion Science and Technology, 31(4), 414-429. https://dx.doi.org/10.1080/01694243.2016.1215768
dc.identifier.doi10.1080/01694243.2016.1215768
dc.identifier.endpage429
dc.identifier.issn0169-4243
dc.identifier.issn1568-5616
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage414
dc.identifier.urihttps://dx.doi.org/10.1080/01694243.2016.1215768
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2926
dc.identifier.volume31
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Adhesion Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdhesion
dc.subjectCytotoxicity
dc.subjectHigh-Performance Liquid Chromatography
dc.subjectL929 Cell Culture
dc.subjectMonomer Release
dc.titleA comparative study on monomer elution and cytotoxicity of different adhesive restoration materials
dc.typeArticle

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