Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases

Basit Öğe Kaydı
dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLopez, Susanna
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorFerri, Raffaele
dc.contributor.authorPascarelli, Maria Teresa
dc.contributor.authorCatania, Valentina
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorBonanni, Laura
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorOnofrj, Marco
dc.contributor.authorStirpe, Paola
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorGarn, Heinrich
dc.contributor.authorFraioli, Lucia
dc.contributor.authorPievanim, Michela
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorDe Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBaşar, Erol
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek-Savas, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorTaylor, John Paul
dc.contributor.authorDe Pandis, Maria Francesca
dc.contributor.authorVacca, Laura
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorStocchi, Fabrizio
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:42Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.descriptionWOS: 000427485900009
dc.descriptionPubMed ID: 29448151
dc.description.abstractObjective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70-0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment.
dc.description.sponsorshipH Marie S. Curie ITN-ETN projecten_US
dc.description.sponsorshipThe present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. Dr. Erol Basar passed away due to health problems on October 28th (November 18th 1938-October 28th 2017) in Istanbul, during the editorial processing of this manuscript. Until the end of his life, he had been working to the development of EEG science and its application in Clinical Neurophysiology. He leaves to all us an invaluable scientific legacy in the Science of Brain Rhythms and Human Cognition. He also leaves a permanent reminder of scientific passion, academic soul, and social responsibility to all fortunate people who met and knew him during his intense life. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-ITNetn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.en_US
dc.identifier.citationBabiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A. ... Stocchi, F. (2018). Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases. Clinical Neurophysiology, 129(4), 766-782. https://dx.doi.org/10.1016/j.clinph.2018.01.009
dc.identifier.doi10.1016/j.clinph.2018.01.009
dc.identifier.endpage782
dc.identifier.issn1388-2457
dc.identifier.issn1872-8952
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage766
dc.identifier.urihttps://dx.doi.org/10.1016/j.clinph.2018.01.009
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2053
dc.identifier.volume129
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofClinical Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFunctional Brain Connectivity
dc.subjectResting State EEG Rhythms
dc.subjectMild Cognitive Impairment Due To
dc.subjectAlzheimer's Disease (ADMCI)
dc.subjectMild Cognitive Impairment Due To
dc.subjectParkinson's Disease (PDMCI)
dc.titleFunctional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Güntekin, Bahar-2018.pdf
Boyut:
2.49 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu