Predictive models for tuberculous pleural effusions in a high tuberculosis prevalence region

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dc.authorid0000-0003-4642-8590
dc.contributor.authorDemirer, Ersin
dc.contributor.authorMiller, Andrew Cate
dc.contributor.authorKunter, Erdoğan
dc.contributor.authorKartalo?lu, Zafer
dc.contributor.authorBarnett, Scott D.
dc.contributor.authorElamin, Elamin M.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:40Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:40Z
dc.date.issued2012
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000302146900015
dc.descriptionPubMed ID: 22057296
dc.description.abstractPatients with pleural effusions who reside in geographic areas with a high prevalence of tuberculosis frequently have similar clinical manifestations of other diseases. The aim of our study was to develop a simple but accurate clinical score for differential diagnosis of tuberculosis pleural effusion (TPE) from non-TB pleural effusion (NTPE). This was an unblinded, prospective study of Turkish patients 18 years of age or older with pleural effusion of indeterminate etiology conducted from June 2003 to June 2005. Unconditional logistic regression models were used to discriminate TPE cases from NTPE cases. Standard errors for the area under the curve (AUC) were calculated using the Mann-Whitney method. Data were statistically significance if two-tailed P < 0.05. A total of 63.3% (157/248) of the patients had TPE while 36.7% (91/248) of the patients had other etiologies for pleural effusions. We were able to provide a predictive model of TPE that included age < 47 years and either pleural fluid adenosine deaminase enzyme (PADA) > 35 U/l or pleural serum protein ratio > 0.710. However, only the combination of age < 47 and PADA > 35 U/l was significant (odds ratio [OR]: 7.46; 95% confidence interval [CI]: 3.99-13.96). The generated summary score (range = 0-6) was significantly predictive of TPE (OR: 2.91; 95% CI: 2.18-3.89) and with high AUC (0.79). We propose an affordable model that includes age < 47 years and PADA > 35 U/l for timely diagnosis of TPE in geographical regions with a high prevalence of TB.
dc.identifier.citationDemirer, E., Miller, A. C., Kunter, E., Kartalo?lu, Z., Barnett, S. D. ve Elamin, E. M. (2012). Predictive models for tuberculous pleural effusions in a high tuberculosis prevalence region. Lung, 190(2), 239-248. https://dx.doi.org/10.1007/s00408-011-9342-z
dc.identifier.doi10.1007/s00408-011-9342-z
dc.identifier.endpage248
dc.identifier.issn0341-2040
dc.identifier.issn1432-1750
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage239
dc.identifier.urihttps://dx.doi.org/10.1007/s00408-011-9342-z
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3392
dc.identifier.volume190
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofLungen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdenosine Deaminase Enzyme
dc.subjectLactate Dehydrogenase Enzyme
dc.subjectPulmonary Tuberculosis
dc.subjectTuberculous Pleural Effusion
dc.titlePredictive models for tuberculous pleural effusions in a high tuberculosis prevalence region
dc.typeArticle

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