Measurement of the serum zonulin levels in patients with acne rosacea

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dc.authorid0000-0002-0011-7570
dc.authorid0000-0003-2350-6381
dc.contributor.authorYüksel, Mavişe
dc.contributor.authorÜlfer, Gözde
dc.date.accessioned2022-02-25T08:55:17Z
dc.date.available2022-02-25T08:55:17Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Although the etiopathogenesis of acne rosacea has not yet been clearly elucidated, it has been discussed over the years that autoimmunity may play a role. Genetic and environmental factors are known to have combined effects in the background of autoimmunity, but it has recently been emphasized that an impaired intestinal barrier system is also involved in the development of the disease. Zonulin is a protein that reversibly increases intestinal permeability. This study aimed to evaluate the zonulin levels in acne rosacea. METHODS: A total of 61 individuals, 30 diagnosed with acne rosacea and 31 healthy controls, were included in this study. There was no difference between the two groups in terms of age, gender, and body mass index. Zonulin was studied using the enzyme-linked immunosorbent assay. RESULTS: The serum zonulin levels were found to be significantly higher in the patient group than in the control group (18.5?±?2.9?ng/ml and 13.2?±?2.7?ng/ml, respectively; p?<?.001). CONCLUSION: This is the first study in the literature to demonstrate that the serum zonulin levels are increased in patients with acne rosacea.
dc.identifier.citationYüksel, M. ve Ülfer, G. (2022). Measurement of the serum zonulin levels in patients with acne rosacea. The Journal of Dermatological Treatment, 33(1), 389-392. http://doi.org/10.1080/09546634.2020.1757015
dc.identifier.doi10.1080/09546634.2020.1757015
dc.identifier.endpage392
dc.identifier.issn1471-1753
dc.identifier.issue1
dc.identifier.pmid32293942
dc.identifier.scopus2-s2.0-85124576697
dc.identifier.scopusqualityQ1
dc.identifier.startpage389
dc.identifier.urihttp://doi.org/10.1080/09546634.2020.1757015
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9009
dc.identifier.volume33
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYüksel, Mavişe
dc.institutionauthorÜlfer, Gözde
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofThe Journal of Dermatological Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcne Rosacea
dc.subjectSmall Intestine
dc.subjectZonulin
dc.titleMeasurement of the serum zonulin levels in patients with acne rosacea
dc.typeArticle

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