Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0002-8084-7855
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorBatmaz, Ahmet Güray
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorYaşar Şirin, Duygu
dc.contributor.authorKaplan, Necati
dc.contributor.authorÖznam, Kadir
dc.contributor.authorAteş, Özkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:17Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:17Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.descriptionWOS: 000443738300011
dc.descriptionPubMed ID: 30186383
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine whether naproxen, an aryl acetic acid derivative with analgesic and anti-inflammatory effects, has a toxic effect on human chondrocytes. Samples containing monolayer primary chondrocyte cultures were prepared following resection from osteochondral tissues obtained from patients with gonarthrosis. Cell viability, toxicity and proliferation and levels of stage-specific embryonic antigen-1, a precursor to human prechondrocytes, were evaluated spectrophotometrically. The results from the untreated control group were compared with those of the study groups, where naproxen was administered in varying doses (1-1,000 mu M). Surface morphologies of the cells were compared using inverted light and environmental scanning electron microscopy. Treatment groups were compared by analysis of variance with Tukey's honest difference post hoc test. P<0.01 was considered to indicate a statistically significant difference. The research revealed significant changes to proliferation and differentiation of chondrocytes in all treatment groups (P<0.01). Naproxen was demonstrated to suppress chondrocyte proliferation and differentiation, which may be an important factor to consider when prescribing this medication to patients.
dc.identifier.citationKaraarslan, N., Batmaz, A., Yılmaz, İ., Özbek, H., Çalışkan, T., Yaşar Şirin, D. ... Ateş, Ö. (2018). Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue. Experimental and Therapeutic Medicine, 16(3), 1647-1654. https://dx.doi.org/10.3892/etm.2018.6351
dc.identifier.doi10.3892/etm.2018.6351
dc.identifier.endpage1654
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage1647
dc.identifier.urihttps://dx.doi.org/10.3892/etm.2018.6351
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1937
dc.identifier.volume16
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpandidos Publications Ltd
dc.relation.ispartofExperimental and Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAryl Acetic Acid
dc.subjectChondrotoxicity
dc.subjectProliferation
dc.subjectStage-Specific Embryonic Antigen-1
dc.titleEffect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue
dc.typeArticle

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