Green tea extract exerts anabolic effects on extracellular matrix of the skin

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dc.authorid0000-0003-1469-2557
dc.contributor.authorTürkoğlu, Murat Metehan
dc.contributor.authorPekmezci, Erkin
dc.contributor.authorKılıç, Songül
dc.date.accessioned2020-09-28T07:54:23Z
dc.date.available2020-09-28T07:54:23Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.description.abstractAn in vitro trial was carried out to reveal the effects of an extract of Camellia sinensis (green tea extract) on the major extracellular matrix components of human skin. After preparing the green tea extract its phytochemical contents were analysed and its effects on gene expression of hyaluronan synthase 2, matrix metalloproteinase-9 and elastase in a human dermal fibroblast cell line were determined. Cell proliferation assay was performed using XTT reagent. Ribonucleic acid isolations were realized by using TRI reagent. Expressions of the relevant enzymes and a control enzyme glyceraldehyde-3-phosphate dehydrogenase were determined using RT-qPCR analysis. Green tea extract caused statistically significant upregulation of hyaluronan synthase-2 gene expression compared to untreated control cells. Also, as a positive outcome, the treatment resulted in significant downregulations of matrix metalloproteinase-9 and elastase gene expressions. Green tea extract was found to have substantial anabolic effects on hyaluronic acid, collagen and elastin. The results obtained in this study might partially explain the molecular basis of the health benefits and antiaging effects of Camellia sinensis on skin.
dc.identifier.citationTürkoğlu, M. M., Pekmezci, E. ve Kılıç, S. (2020). Green tea extract exerts anabolic effects on extracellular matrix of the skin. Indian Journal of Pharmaceutical Sciences, 82(2), 368-373. https://dx.doi.org/10.36468/pharmaceutical-sciences.658
dc.identifier.doi10.36468/pharmaceutical-sciences.658
dc.identifier.endpage373
dc.identifier.issn0250-474X
dc.identifier.issn1998-3743
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage368
dc.identifier.urihttps://dx.doi.org/10.36468/pharmaceutical-sciences.658
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5872
dc.identifier.volume82
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIndian Pharmaceutical Association
dc.relation.ispartofIndian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/*
dc.subjectCamellia Sinensis
dc.subjectGreen Tea
dc.subjectHyaluronan Synthase
dc.subjectMatrix Metalloproteinase
dc.subjectElastase
dc.titleGreen tea extract exerts anabolic effects on extracellular matrix of the skin
dc.typeArticle

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