Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation

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dc.authorid0000-0002-3887-4569
dc.contributor.authorCevizci, Raşit
dc.contributor.authorDüzlü, Mehmet
dc.contributor.authorDündar, Yasemin
dc.contributor.authorNoyanalpan, Ningur
dc.contributor.authorSultan, Nedim
dc.contributor.authorTutar, Hakan
dc.contributor.authorBayazıt, Yıldırım Ahmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:18Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:18Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000354623800009
dc.descriptionPubMed ID: 24570174
dc.description.abstractThe purpose of the study is to assess the effect of a novel quorum sensing inhibitor (QSI), coded as 'yd 47', against otitis media and biofilm formation on Cochlear implants (CIs). Small pieces cut from cochlear implant were implanted under the skin in the retroauricular area on both sides of four guinea pigs. The implant pieces in the study and control sides were implanted in Streptococcus pneumoniae strain solution and saline, respectively. The right and left middle ears were also instilled with a solution containing pneumococci and saline, respectively. The animals were only given an intraperitoneal 'yd 47' twice daily for three months to be assessed later with electron microscopy. Clinical examination with palpation, inspection and otoscopy did not reveal any sign of implant infection or otitis media. In the study and control implant materials, soft tissues around the implant and tympanic membranes, there was no biofilm formation by pneumococci. Contamination by various cells and some rod-shaped bacteria (not diplococcic) were seen in some of the materials. In conclusion, the novel QSI seems promising in the prevention of otitis media and biofilm formation on CIs by pneumococci.
dc.description.sponsorshipMEDers(R) companyen_US
dc.description.sponsorshipThis study was supported financialy by MEDers (R) company (Authorized Distrubutor of MED-EL (R) company in Turkey). I (we) certifiy that we don't have any interest in this company.en_US
dc.identifier.citationCevizci, R., Düzlü, M., Dündar, Y., Noyanalpan, N., Sultan, N., Tutar, H. ve Bayazıt, Y. A. (2015). Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation. European Archives of Oto-Rhino-Laryngology, 272(6), 1389-1393. https://dx.doi.org/10.1007/s00405-014-2942-5
dc.identifier.doi10.1007/s00405-014-2942-5
dc.identifier.endpage1393
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage1389
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-014-2942-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2379
dc.identifier.volume272
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBiofilm
dc.subjectQuorum Sensing
dc.subjectCochlear Implant Infection
dc.titlePreliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation
dc.typeArticle

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