Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authordel Percio, Claudio
dc.contributor.authorPascarelli, Maria Teresa
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLopez, Susanna
dc.contributor.authorRizzo, Marco
dc.contributor.authorFerri, Rafaele
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorSalvetti, Marco
dc.contributor.authorCipollini, Virginia
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorOnofrj, Marco
dc.contributor.authorStirpe, Paola
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorAarsland, Dag
dc.contributor.authorParnetti, Lucilla
dc.contributor.authorFarotti, Lucia
dc.contributor.authorMarizzoni, Moira
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorDe Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorTaylor, John Paul
dc.contributor.authorMcKeith, Ian
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorHampel, Harald
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorde Pandis, Maria Francesca
dc.contributor.authorBonanni, Laura
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:35Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.descriptionWOS: 000465302200012
dc.descriptionPubMed ID: 30797169
dc.description.abstractPrevious evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.
dc.description.sponsorshipH2020 Marie S. Curie ITN-ETN project; H2020-TWINN-2015 projecten_US
dc.description.sponsorshipThe present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this article. The research activities of the Unit of Sapienza University of Rome were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiagitn-etn.eu/) and the H2020-TWINN-2015 project with the short title "SynaNet" (https://www.synanet2020.com/). The authors thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.en_US
dc.identifier.citationBabiloni, C., del Percio, C., Pascarelli, M. T., Lizio, R. Noce, G., Lopez, S. ... Bonanni, L. (2019). Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases. Neurobiology of Aging, 77, 112-127. https://dx.doi.org/10.1016/j.neurobiolaging.2019.01.013
dc.identifier.doi10.1016/j.neurobiolaging.2019.01.013
dc.identifier.endpage127
dc.identifier.issn0197-4580
dc.identifier.issn1558-1497
dc.identifier.scopusqualityQ1
dc.identifier.startpage112
dc.identifier.urihttps://dx.doi.org/10.1016/j.neurobiolaging.2019.01.013
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1665
dc.identifier.volume77
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofNeurobiology of Agingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectFunctional Brain Connectivity
dc.subjectResting State EEG Rhythms
dc.subjectMild Cognitive Impairment Due To
dc.subjectAlzheimer's Disease (ADMCI)
dc.subjectMild Cognitive Impairment Due To Dementia With Lewy Body (DLBMCI)
dc.titleAbnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases
dc.typeArticle

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