In vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolates

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dc.authorid0000-0001-8022-7325
dc.contributor.authorMataracı Kara, Emel
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorÖzbek Çelik, Berna
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:32Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:32Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000471951900029
dc.descriptionPubMed ID: 30576787
dc.description.abstractObjectives: Infections caused by multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) are a growing problem because of the limited options for treatment. The number of antimicrobials that are currently being developed is still insufficient to control this global threat. Combination therapies of antibiotics with different antimicrobial mechanisms have been proposed as the best options for treating MDR A. baumannii infections. The objective of this study was to investigate the in-vitro effectiveness of ceftazidime/avibactam alone or in combination with antibiotics against MDR A. baumannii isolates using time-kill assays. Methods: Forty clinical MDR strains were screened, and minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of ceftazidime/avibactam, colistin, levofloxacin, meropenem, tigecycline, and tobramycin were determined by microbroth dilution method. The in-vitro synergistic activities of ceftazidime/avibactam with antibiotic combinations were determined by time-kill assays at 1 x MIC and 4 x MIC against five MDR A. baumannii isolates. Results: Based on MIC results, all isolates of A. baumannii were resistant to ceftazidime/avibactam, except for AB-5. All isolates were found to be resistant to meropenem and levofloxacin. At 4 x MIC, all of the tested antibiotics showed bactericidal effect (>= 3 log (10) killing). The synergistic activities of ceftazidime/avibactam + colistin, ceftazidime/avibactam + tobramycin and ceftazidime/avibactam + tigecycline combinations at 1 x MIC were observed against studied 5/5, 4/5 and 4/5 strains, respectively. Furthermore, all of the tested combinations at 4 x MIC were additive at 24 h. No antagonism was observed. Conclusions: The findings of this study suggest that a significant bactericidal effect was seen with all tested combinations. These findings present significant implications for antibiotic choice for the treatment of infections caused by MDR A. baumannii.
dc.description.sponsorshipResearch Fund of the University of Istanbul (Istanbul, Turkey) [21897]en_US
dc.description.sponsorshipThis work was supported by a grant from the Research Fund of the University of Istanbul (Istanbul, Turkey). Project number: 21897.en_US
dc.identifier.citationMataracı Kara, E., Yılmaz, M. ve Özbek Çelik, B. (2019). In vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolates. Journal of Global Antimicrobial Resistance, 17, 137-141. https://dx.doi.org/10.1016/j.jgar.2018.12.004
dc.identifier.doi10.1016/j.jgar.2018.12.004
dc.identifier.endpage141
dc.identifier.issn2213-7165
dc.identifier.issn2213-7173
dc.identifier.scopusqualityQ2
dc.identifier.startpage137
dc.identifier.urihttps://dx.doi.org/10.1016/j.jgar.2018.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1626
dc.identifier.volume17
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Ltd
dc.relation.ispartofJournal of Global Antimicrobial Resistanceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCeftazidime/Avibactam
dc.subjectCombination
dc.subjectBeta-Lactam Inhibitors
dc.subjectGram-Negative
dc.subjectSynergy
dc.titleIn vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolates
dc.typeArticle

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