On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese

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dc.authorid0000-0002-0675-1839
dc.contributor.authorDaşkın Fakıoğlu, Fatma Betül
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorEmekli, Nesrin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:12Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:12Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractAdipose tissue plays an important role in energy balance by secretion of various adipokines. Obesity is excessive fat accumulation in the body. The aim of this study is to examine the association of apelin, an adipokine secreted from fat tissue, with antioxidant system, glucose and lipid parameters in obese and control cases. After approval has been taken from the Ethics Committee, 61 obese and 24 control people were included in the study. The ages in the study group ranges between 18 and 75. The body mass index (BMI) is >24.9 in obese people, and it ranges between 18.5-24.9 in control cases. Apelin was calculated using the ELISA method, total oxidant and total antioxidant levels were calculated using the colorimetric method, fasting blood glucose, insulin, TG, LDL and HDL levels were calculated using the photometric method, insulin resistance was calculated using the HOMA-IR method. Serum apelin levels were not found to differ between obese and control groups (p>0.05). Total antioxidant level (TAS) decreased in the obese group (p<0.001) while total oxidant level (TOS) remained the same. The Oxidative Stres Index (OSI) increased (p<0.001) in the obese group. In the obese group, glucose and insulin resistance were high (p<0.05) while serum insulin levels were the same as in the control group (p>0.05). In our study group, lipid parameters did not exhibit any difference in the obese and control groups. There was a significant relationship at p<0.05 level between triglyceride values in the control and obese case groups, while there were no significant differences among other lipid parameters. As a result; we think that further studies are needed to understand the effect of apelin, which is released from fat tissue and is active in energy metabolism.
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit: 86770134-604/101en_US
dc.identifier.citationDaşkın Fakıoğlu, F. B., Yiğitbaşı, T. ve Emekli, N. (2017). On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese. Acta Pharmaceutica Sciencia, 55(4), 17-25. https://dx.doi.org/10.23893/1307-2080.APS.05523
dc.identifier.doi10.23893/1307-2080.APS.05523
dc.identifier.endpage25
dc.identifier.issn1307-2080
dc.identifier.issue4
dc.identifier.scopusqualityQ4
dc.identifier.startpage17
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1093
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05523
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdipose Tissue
dc.subjectApelin
dc.subjectObesity
dc.subjectOxidative Stress
dc.titleOn the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese
dc.typeArticle

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