A gender-based analysis of disease activity and its relationship with anxiety, depression, fatigue, and fibromyalgia in psoriatic arthritis

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dc.authorid0000-0002-1111-3110
dc.contributor.authorDuruöz, Mehmet Tuncay
dc.contributor.authorGezer, Halise Hande
dc.contributor.authorNas, Kemal
dc.contributor.authorKılıç, Erkan
dc.contributor.authorSargın, Betül
dc.contributor.authorKasman, Sevtap Acer
dc.contributor.authorAlkan, Hakan
dc.contributor.authorŞahin, Nilay
dc.contributor.authorCengiz, Gizem
dc.contributor.authorCüzdan, Nihan
dc.contributor.authorGezer, İlknur Albayrak
dc.contributor.authorKeskin, Dilek
dc.contributor.authorMülkoğlu, Cevriye
dc.contributor.authorResorlu, Hatice
dc.contributor.authorAtaman, Şebnem
dc.contributor.authorBal, Ajda
dc.contributor.authorKücükakkaş, Okan
dc.contributor.authorYurdakul, Ozan Volkan
dc.contributor.authorAlkan Melikoğlu, Meltem
dc.contributor.authorAydın, Yıldıray
dc.contributor.authorAyhan, Fikriye Figen
dc.contributor.authorBodur, Hatice
dc.contributor.authorÇalış, Mustafa
dc.contributor.authorÇapkın, Erhan
dc.contributor.authorDevrimsel, Gül
dc.contributor.authorGök, Kevser
dc.contributor.authorHizmetli, Sami
dc.contributor.authorKemanlı, Ayhan
dc.contributor.authorKeskin, Yaşar
dc.contributor.authorKocabaş, Hilal
dc.contributor.authorKütlük, Öznur
dc.contributor.authorSen, Nesrin
dc.contributor.authorŞendur, Ömer Faruk
dc.contributor.authorTekeoğlu, İbrahim
dc.contributor.authorTolu, Sena
dc.contributor.authorToprak, Murat
dc.contributor.authorTuncer, Tiraje
dc.date.accessioned2020-03-04T12:04:02Z
dc.date.available2020-03-04T12:04:02Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.description.abstractBackground/Purpose: This study sought to compare the disease activity and its relationship with anxiety, depression, fatigue, and fibromyalgia of patients with psoriatic arthritis (PsA) between female and male gender in a Turkish population. Methods: This multi-center Turkish League Against Rheumatism (TLAR) Network study included 1134 patients (726 females, 408 males) diagnosed with PsA according to the CASPAR criteria. Demographic and clinic parameters of the patients were recorded. Disease activity was evaluated using the scores of DAS28, DAPSA, cDAPSA, MDA, VLDA, and BASDAI. Health Assessment Questionnaire (HAQ), SF-36, Hospital Anxiety and Depression Scale (HAD), fatigue VAS (0-10), and Fibromyalgia Rapid Screening Tool (FIRST) were assessed. Disease activity and remission rates were compared in male and female patients, and their relationship with fatigue, anxiety, depression, and fibromyalgia scores was analyzed. The Spearman correlation coefficient was used to assess correlations. Comparisons were made using the Mann-Whitney U and chi-squared tests. p< 0.05 was considered significant. Results: The mean age of the patients was 47.4 years (SD:12.1) for females, 46 years (SD:12.2) for males (Table-1). Disease activity scores of DAS28, DAPSA, cDAPSA, and BASDAI were significantly higher in women than in men (p< 0.05) (Table-2), with men having both higher remission and low-activity rates. There was a significant difference in the rate of MDA in favor of men (p< 0.05), but not in the rate of VLDA. The frequencies of dactylitis, enthesitis, inflammatory bowel disease, and arthritis were similar in men and women, while men had a higher incidence of spondylitis (p< 0.05). Both men and women with MDA had significant improvements in the scores of fatigue, HAQ, FIRST, anxiety and depression as well as in SF-36 subscales as compared with their counterparts without MDA (p< 0.05). Overall, although there was no significant between-group difference in age, body mass index, and disease duration, women had significantly higher anxiety, depression, and FIRST scores (fibromyalgia) compared with men (p< 0.05) (Table-2). In both men and women, disease activity scores of DAPSA, DAS28, and BASDAI were significantly correlated with the scores of FIRST, anxiety, depression, fatigue, and HAQ (p< 0.05). Conclusion: In patients with PsA, women seem to have lower levels of remission and higher levels of disease activity than men. In both women and men, disease activity scores are significantly correlated with fatigue, functional status, anxiety, depression, fibromyalgia, and quality of life.
dc.identifier.citationDuruöz, M. T., Gezer, H. H., Nas, K., Kılıç, E., Sargın, B., Acer Kasman, S., Alkan, H. ... Tuncer, T. (2019). A gender-based analysis of disease activity and its relationship with anxiety, depression, fatigue, and fibromyalgia in psoriatic arthritis. Arthritis Rheumatology. Wiley.
dc.identifier.issn2326-5191
dc.identifier.issn2326-5205
dc.identifier.issueSupplement: 10
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4984
dc.identifier.volume71
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofArthritis Rheumatologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDisease Activity
dc.subjectFatigue and Derpression
dc.subjectGender
dc.subjectPsoriatic Arthritis
dc.titleA gender-based analysis of disease activity and its relationship with anxiety, depression, fatigue, and fibromyalgia in psoriatic arthritis
dc.typeConference Object

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