Serum and follicular fluid irisin levels in poor and high responder women undergoing IVF/ICSI

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dc.authorid0000-0003-0640-4420
dc.contributor.authorAcet, Mustafa
dc.contributor.authorÇelik, Nilüfer
dc.contributor.authorAcet, Tuba
dc.contributor.authorİlhan, Selçuk
dc.contributor.authorYardım, Meltem
dc.contributor.authorAktün, Hale Lebriz
dc.contributor.authorBaşaranoğlu, Serdar
dc.contributor.authorDeregözü, Ayşegül
dc.contributor.authorAydın, Süleyman
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:55:57Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:55:57Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000382459500005
dc.descriptionPubMed ID: 27249590
dc.description.abstractOBJECTIVE: We examined the follicular fluid (FF) and serum levels of irisin in high and poor responders undergoing IVF/ICSI to test whether irisin has a role in the metabolic regulation of energy homeostasis in growing follicle. PATIENTS AND METHODS: Twenty infertile women with PCOS and 20 poor responder participants undergoing controlled ovarian stimulation (COS) with GnRH antagonist protocol for IVF/ICSI treatment were allocated. Blood was obtained at the time of oocyte retrieval. The follicular fluid content of mature follicles was collected from both high and poor responder women. Irisin levels were measured by using EIA. RESULTS: There was no significant difference between serum and FF-irisin levels in women with PCOS. (11.18 +/- 5.14 mu g/mL vs. 11.06 +/- 4.93 mu g/mL, p < 0.96). In contrast, serum levels of irisin in poor responders were significantly higher than in the FF-irisin levels (13.13 +/- 4.27 mu g/mL vs. 10.09 +/- 4.14 mu g/mL, p < 0.01). FF-irisin levels of PCOS subjects were positively and significantly correlated with serum levels of irisin (r: 0.81, p < 0.00). Serum irisin was positively associated with serum levels of total testosterone but was negatively associated with HOMA-IR in the overall patient population. FF-irisin levels were also noted to be negatively correlated with HOMA-IR. Although there is no correlation between serum irisin and AMH levels, FF irisin levels were negatively correlated with serum AMH levels in PCOS subjects. Contrary to PCOS group there were no significant correlation between serum and FF-irisin levels in poor responder group (r: 0.21; p < 0.35). CONCLUSIONS: The present study is the first attempt to explore the role of irisin in oocyte development by measuring FF and serum levels of this molecules in patients with poor and high responders undergoing IVF/ICSI.
dc.identifier.citationAcet, M., Çelik, N., Acet, T., İlhan, S., Yardım, M., Aktün, H. L. ... Aydın, S. (2016). Serum and follicular fluid irisin levels in poor and high responder women undergoing IVF/ICSI. European Review For Medical And Pharmacological Sciences, 20(10), 1940-1946.
dc.identifier.endpage1946
dc.identifier.issn1128-3602
dc.identifier.issue10
dc.identifier.scopusqualityQ2
dc.identifier.startpage1940
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2493
dc.identifier.volume20
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPCOS
dc.subjectPoor Responder
dc.subjectSerum
dc.subjectFollicular Fluid
dc.subjectLrisin
dc.titleSerum and follicular fluid irisin levels in poor and high responder women undergoing IVF/ICSI
dc.typeArticle

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