Outcome of autologous hematopoietic stem cell transplantation in children and adolescents with relapsed or refractory Hodgkin's lymphoma

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dc.authorid0000-0002-1407-2334
dc.contributor.authorHazar, Volkan
dc.contributor.authorKesik, Vural
dc.contributor.authorAksoylar, Serap
dc.contributor.authorKarakükçü, Musa
dc.contributor.authorÖztürk, Gülyüz
dc.contributor.authorKüpesiz, Alphan
dc.contributor.authorAtaş, Erman
dc.contributor.authorÖniz, Haldun
dc.contributor.authorKansoy, Savaş
dc.contributor.authorÜnal, Ekrem
dc.contributor.authorTanyeli, Atila
dc.contributor.authorErbey, Fatih
dc.contributor.authorElli, Murat
dc.contributor.authorTaçyıldız, Nurdan
dc.contributor.authorKarasu, Gülsün Tezcan
dc.contributor.authorKoçak, Ülker
dc.contributor.authorAnak, Şema Sema
dc.contributor.authorYılmaz Bengoa, Şebnem
dc.contributor.authorSezgin, Gülay
dc.contributor.authorAtay, Didem
dc.contributor.authorÜnal, Emel
dc.contributor.authorUygun, Vedat
dc.contributor.authorKurucu, Nilgün
dc.contributor.authorKaya, Zühre
dc.contributor.authorYeşilipek, Akif
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:29Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:29Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000362580100020
dc.descriptionPubMed ID: 26346042
dc.description.abstractThis study evaluates the outcome of 66 pediatric patients with rrHL who underwent autoHSCT. Twenty-nine patients experienced early relapse, and 19 patients experienced late relapse. Of 18 newly diagnosed with HL, 13 were primary refractory disease and five had late responsive disease. At the time of transplantation, only 68% of the patients were chemosensitive. The majority of patients received BCNU+etoposide+ara-C+melphalan for conditioning (45/66), and peripheral blood (56/66) was used as a source of stem cells. After a median follow-up period of 39months, 46 patients were alive. At fiveyr, the probabilities of OS, EFS, the relapse rate, and the non-relapse mortality rate were 63.1%, 54.3%, 36.4%, and 9.1%, respectively. The probability of EFS in chemosensitive and chemoresistant patients at fiveyr was 72.3% and 19%, respectively (p<0.001). Multivariate analysis showed that chemoresistant disease at the time of transplantation was the only factor predicting limited both OS (hazard ratio=4.073) and EFS (hazard ratio=4.599). AutoHSCT plays an important role for the treatment of rrHL in children and adolescents, and survival rates are better for patients with chemosensitive disease at the time of transplantation.
dc.identifier.citationHazar, V., Kesik, V., Aksoylar, S., Karakükçü, M., Öztürk, G., Küpesiz, A. (2015). Outcome of autologous hematopoietic stem cell transplantation in children and adolescents with relapsed or refractory Hodgkin's lymphoma. Pediatric Transplantation, 19(7), 745-752. https://dx.doi.org/10.1111/petr.12573
dc.identifier.doi10.1111/petr.12573
dc.identifier.endpage752
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage745
dc.identifier.urihttps://dx.doi.org/10.1111/petr.12573
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3657
dc.identifier.volume19
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHodgkin's Lymphoma
dc.subjectChildren and Adolescents
dc.subjectRelapse
dc.subjectRefractory
dc.subjectAutologous Hematopoietic Stem Cell Transplantation
dc.subjectSurvival
dc.titleOutcome of autologous hematopoietic stem cell transplantation in children and adolescents with relapsed or refractory Hodgkin's lymphoma
dc.typeArticle

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