Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to alzheimer’s disease
| dc.authorid | 0000-0002-0860-0524 | |
| dc.authorid | 0000-0002-7715-3035 | |
| dc.authorid | 0000-0003-4292-5717 | |
| dc.contributor.author | Babiloni, Claudio | |
| dc.contributor.author | Lopez, Susanna | |
| dc.contributor.author | Noce, Giuseppe | |
| dc.contributor.author | Ferri, Raffaele | |
| dc.contributor.author | Panerai, Simonetta | |
| dc.contributor.author | Catania, Valentina | |
| dc.contributor.author | Carducci, Filippo | |
| dc.date.accessioned | 2023-11-13T08:09:14Z | |
| dc.date.available | 2023-11-13T08:09:14Z | |
| dc.date.issued | 2023 | |
| dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | |
| dc.description.abstract | Here we tested the hypothesis of a relationship between the cortical default mode network (DMN) structural integrity and the resting-state electroencephalographic (rsEEG) rhythms in patients with Alzheimer’s disease with dementia (ADD). Clinical and instrumental datasets in 45 ADD patients and 40 normal elderly (Nold) persons originated from the PDWAVES Consortium (www.pdwaves.eu). Individual rsEEG delta, theta, alpha, and fixed beta and gamma bands were considered. Freeware platforms served to derive (1) the (gray matter) volume of the DMN, dorsal attention (DAN), and sensorimotor (SMN) cortical networks and (2) the rsEEG cortical eLORETA source activities. We found a significant positive association between the DMN gray matter volume, the rsEEG alpha source activity estimated in the posterior DMN nodes (parietal and posterior cingulate cortex), and the global cognitive status in the Nold and ADD participants. Compared with the Nold, the ADD group showed lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status. This effect was not observed in the DAN and SMN. These results suggest that the DMN structural integrity and the rsEEG alpha source activities in the DMN posterior hubs may be related and predict the global cognitive status in ADD and Nold persons. | |
| dc.description.sponsorship | IRCCS San Raffaele Pisana of Rome ; Ministero della Salute | en_US |
| dc.identifier.citation | Babiloni, C., Lopez, S., Noce, G., Ferri, R., Panerai, S., Catania, V. ... Carducci, F. (2023). Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to alzheimer’s disease. Cerebral Cortex, 33(20), 10514-10527. https://dx.doi.org/10.1093/cercor/bhad300 | |
| dc.identifier.doi | 10.1093/cercor/bhad300 | |
| dc.identifier.endpage | 10527 | |
| dc.identifier.issn | 1047-3211 | |
| dc.identifier.issn | 1460-2199 | |
| dc.identifier.issue | 20 | |
| dc.identifier.pmid | 37615301 | |
| dc.identifier.scopus | 2-s2.0-85175473562 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 10514 | |
| dc.identifier.uri | https://dx.doi.org/10.1093/cercor/bhad300 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/11762 | |
| dc.identifier.volume | 33 | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Güntekin, Bahar | |
| dc.institutionauthor | Yıldırım, Ebru | |
| dc.institutionauthor | Hanoğlu, Lütfü | |
| dc.language.iso | en | |
| dc.publisher | Oxford University Press | |
| dc.relation.ispartof | Cerebral Cortex | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Structural Magnetic Resonance Imaging (sMRI) | |
| dc.subject | Default Mode Network (DMN) | |
| dc.subject | Resting State Electroencephalographic (rsEEG) Alpha Rhythms | |
| dc.subject | Alzheimer’s Disease With Dementia (ADD) | |
| dc.subject | Exact Low-Resolution Brain Electromagnetic Source Tomography (eLORETA) | |
| dc.title | Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to alzheimer’s disease | |
| dc.type | Article |
