The effect of human amniotic fluid on mandibular distraction osteogenesis

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dc.contributor.authorGökçe, Sıla Mermut
dc.contributor.authorKaraçaylı, Ümit
dc.contributor.authorNalçaci, Ruhi
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorÖzgöçmen, Meltem
dc.contributor.authorKaraşahin, Kazım Emre
dc.contributor.authorGökçe, Hasan Suat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:45Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:45Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Protetik Diş Tedavisi Ana Bilim Dalı
dc.descriptionWOS: 000350527600018
dc.descriptionPubMed ID: 25457823
dc.description.abstractThe aim of this study was to evaluate the effects of local administration of human amniotic fluid (HAF) on newly formed bone obtained by mandibular distraction osteogenesis (DO) with histomorphometry. A unilateral mandibular osteotomy at the left corpus was performed in 32 adult male rabbits. After a 5-day latency period, the left mandibles were lengthened by mandibular DO over 5 days, at a rate of 1 mm/day, via a custom-made distractor. After the distraction, the rabbits were divided randomly into four groups: 0.3 ml HAF was injected into the distraction gap followed by 21 (group 1) or 45 (group 2) days of consolidation; or 0.3 ml normal saline (NS) was administered followed by 21 (group 3) or 45 (group 4) days of consolidation. Mandibles were removed at the end of the consolidation period and investigated histomorphometrically. The newly formed bone area (NFBA) and number of fibroblasts increased significantly in the HAF groups compared to the NS groups (NFBA: group 1 vs. group 3, P < 0.05; group 2 vs. group 4, P < 0.01; fibroblasts: group 1 vs. group 3, and group 2 vs. group 4, P < 0.05), and also in both 45-day consolidation groups compared to the 21-day consolidation groups (NFBA: group 1 vs. group 2, and group 3 vs. group 4, P < 0.001; fibroblasts: group 1 vs. group 2, and group 3 vs. group 4, P < 0.01). Additionally, the numbers of osteoblasts and capillaries were increased significantly at 45 days of consolidation compared to 21 days in both the HAF and NS groups (osteoblasts: group 1 vs. group 2, P < 0.01; group 3 vs. group 4, P < 0.05; capillaries: group 1 vs. group 2, and group 3 vs. group 4, P < 0.01). Histomorphometric analysis demonstrated that local HAF administration effectively accelerated bone formation. Thus, a HAF injection procedure could improve new bone formation around the bone in maxillofacial operations such as DO.
dc.identifier.citationGökçe, S. M., Karaçaylı, Ü., Nalçacı, R., Avunduk, M. C., Özgöçmen, M., Karaşahin, K. E., ve Gökçe, H. (2015). The effect of human amniotic fluid on mandibular distraction osteogenesis. International Journal of Oral and Maxillofacial Surgery, 44(3), 404-411. https://dx.doi.org/10.1016/j.ijom.2014.10.002
dc.identifier.doi10.1016/j.ijom.2014.10.002
dc.identifier.endpage411
dc.identifier.issn0901-5027
dc.identifier.issn1399-0020
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage404
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijom.2014.10.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2807
dc.identifier.volume44
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHuman Amniotic Fluid
dc.subjectDistraction Osteogenesis
dc.subjectHistomorphometry
dc.subjectBone
dc.titleThe effect of human amniotic fluid on mandibular distraction osteogenesis
dc.typeArticle

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