Pregabalin attenuates carrageenan induced acute inflammation in rats by inhibiting proinflammatory cytokine levels

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dc.authorid0000-0002-4966-1745
dc.contributor.authorKılıç, Fatma Sultan
dc.contributor.authorKaygısız, Bilgin
dc.contributor.authorAydın, Şule
dc.contributor.authorYıldırım, Cafer
dc.contributor.authorKarimkhan, Hadi
dc.contributor.authorÖner, Setenay
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:12Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:12Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.descriptionWOS: 000450354500005
dc.descriptionPubMed ID: 30515034
dc.description.abstractObjective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1 beta (IL-1 beta) acting as acute phase cytokines in inflammation, and antiinflammatory cytokine IL-10, in rats. Materials and Methods: Single doses of PGB 30, 50, and 100 mg/kg and indomethacin (INDO) 5 mg/kg in the treatment groups and saline in the control group were injected once intraperitoneally prior to administration of 100 mu l of 1% CAR into the right hind paw of the rats. The paw thickness was measured using gauge calipers (Vernier calipers) before (0 hour) and every hour afterwards for 6 hours following the inflammation induction. The cytokine levels in the blood serum obtained intracardiacally were determined after 6 hours using the enzyme-linked immunosorbent assay method. p < 0.05 was considered statistically significant. Results: There was no significant difference between the 0 and 6th hour considering the paw thickness in all groups, except in the CAR group. CAR significantly increased the paw thickness at 6 hours compared to the 0 hour. All doses of PGB and INDO significantly reduced the paw thickness after 6 hours compared to the CAR group. The TNF-alpha and IL-1 beta levels in the PGB and INDO groups were comparable to the control group, whereas in the CAR group, these levels were increased. The IL-10 level was enhanced in the PGB 50 mg/kg and INDO groups. Conclusion: It was observed that all doses of PGB exerted anti-inflammatory-like effects comparable to INDO, supported by their effects on the levels of cytokines.
dc.description.sponsorshipScientific Research Commission of Eskisehir Osmangazi University [2015-946]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Commission of Eskisehir Osmangazi University (Project numbers: 2015-946).en_US
dc.identifier.citationKılıç, F., Kaygısız, B., Aydın, Ş., Yıldırım, C., Karımkhan, H. ve Öner, S. (2018). Pregabalin attenuates carrageenan induced acute inflammation in rats by inhibiting proinflammatory cytokine levels. Eurasian Journal of Medicine, 50(3) 156-159. https://dx.doi.org/10.5152/eurasianjmed.2018.17261
dc.identifier.doi10.5152/eurasianjmed.2018.17261
dc.identifier.endpage159
dc.identifier.issn1308-8734
dc.identifier.issn1308-8742
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage156
dc.identifier.urihttps://dx.doi.org/10.5152/eurasianjmed.2018.17261
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2362
dc.identifier.volume50
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAVES
dc.relation.ispartofEurasian Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPregabalin
dc.subjectInflammation
dc.subjectAnti-Inflammatory Effect
dc.subjectCytokines
dc.subjectRat
dc.titlePregabalin attenuates carrageenan induced acute inflammation in rats by inhibiting proinflammatory cytokine levels
dc.typeArticle

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