Are soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy?

Basit Öğe Kaydı
dc.contributor.authorÖnür, Seda Tural
dc.contributor.authorSökücü, Sinem Nedime
dc.contributor.authorDalar, Levent
dc.contributor.authorSeyhan, Ekrem Cengiz
dc.contributor.authorAkbaş, Ayşegül
dc.contributor.authorAltın, Sedat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:25Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:25Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000350052900006
dc.descriptionPubMed ID: 25549699
dc.description.abstractBackground: The differential diagnostic utilities of the levels of soluble interleukin (IL)-12p40 and the IL-2 receptor in sera and pleural effusions were evaluated in patients with exudative pleural effusions. Methods: We enrolled a total of 120 patients with exudative pleural effusions. The clinical, radiological, and histopathological diagnoses were tuberculous pleurisy in 52, malignant pleurisy in 39, and parapneumonic effusions in 29 patients. Results: We measured serum IL-12p40 and adenosine deaminase (ADA) levels in patients with tuberculous pleurisy and in a control group treated for pleural effusion to determine if such levels were useful in the diagnosis of pleural effusion (p < 0.005). Definite microbiological or histopathological diagnoses of tuberculous pleurisy or pleural effusion were recorded, and we found that ADA and serum soluble IL-2 receptor levels aided in diagnosis (p < 0.001). The levels of ADA and soluble IL-2 in pleural effusions afforded sensitivities and specificities of 84.62% and 82.69% and of 70.59% and 80.88%, respectively. The soluble IL-2 receptor level afforded a sensitivity and specificity of 82.69% and 52.9%. IL-12p40 levels in pleural effusions and sera afforded sensitivities and specifi cities of 80.77% and 80.77% and of 60.29% and 39.71%, respectively. Conclusion: Soluble IL-2 receptor levels in patients with tuberculous pleurisy serve as markers of disease in non-endemic countries, similarly to ADA levels.
dc.identifier.citationÖnür, S. T., Sökücü, S. N., Dalar, L., Seyhan, E. C., Akbaş, A. ve Altın, S. (2015). Are soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy? Infectious Diseases, 47(3), 150-155. https://dx.doi.org/10.3109/00365548.2014.975278
dc.identifier.doi10.3109/00365548.2014.975278
dc.identifier.endpage155
dc.identifier.issn2374-4235
dc.identifier.issn2374-4243
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage150
dc.identifier.urihttps://dx.doi.org/10.3109/00365548.2014.975278
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2698
dc.identifier.volume47
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofInfectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTuberculosis
dc.subjectPleural Effusion
dc.subjectSoluble IL-2 Receptor
dc.subjectIL-12p40
dc.subjectAdenosine Deaminase
dc.titleAre soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy?
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
seyhan, ekrem cengiz_2015.pdf
Boyut:
174.57 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu