Effect of varicocele repair on conventional sperm parameters in infertile patients with clinical varicocele: A systematic review and metaanalysis.

Basit Öğe Kaydı
dc.contributor.authorAgarwal, Ashok
dc.contributor.authorCannarella, Rossella
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorBoitrelle, Florence
dc.contributor.authorHamoda, Taha Abdel-Meguid
dc.contributor.authorGül, Murat
dc.contributor.authorSalvio, Gianmaria
dc.contributor.authorShah, Rupin
dc.date.accessioned2023-03-17T09:11:07Z
dc.date.available2023-03-17T09:11:07Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractObjective Varicocele is present in almost 35-40% of men presenting with primary infertility. Despite the significant role of varicocele in the pathogenesis of male infertility, the impact of varicocele repair (VR) on conventional semen parameters remains controversial. To the best of our knowledge, only a few systematic reviews and meta-analyses (SRMA) have evaluated the impact of VR on sperm concentration, total motility, and progressive motility using a before-after analytic approach for analyzing 22, 17, and 5 prospective uncontrolled trials, respectively. Indeed, the majority of SRMAs have focused on pregnancy rate as an outcome. This study aimed to evaluate the effect of VR on conventional semen parameters in infertile patients with clinical varicocele compared to untreated controls. Materials and Methods Literature search was performed in Scopus, PubMed, Ovid, Embase, and Cochrane databases using the PICO model (Population: Infertile patients with clinical varicocele; Intervention: Varicocele repair; Comparison: No treatment; Outcomes: Sperm concentration, sperm total count, sperm progressive motility, sperm total motility, and semen volume). Both randomized-controlled trials (RCTs) and observational studies were included. Results 1632 abstracts were initially assessed for eligibility. 16 studies were finally included with a total of 2420 infertile patients with clinical varicocele (1424 patients treated with VR vs. 996 untreated controls). The analysis showed significantly improved post-operative sperm parameters in the VR group compared to controls: sperm concentration [standardized mean difference (SMD) 1.87 (95% CI: 1.25, 2.48); p<0.01; I 2 =97.6%], total sperm count [SMD 1.89 (95% CI: 0.57, 3.22); p<0.05; I 2 =97.8%], sperm progressive motility [SMD 3.30% (95% CI: 2.16, 4.44); p<0.01; I 2 =98.4%], total sperm motility [SMD 0.89% (95% CI: 0.04, 1.74); p=0.04; I 2 =97.4%] and normal sperm morphology [SMD 1.68% (95% CI: 0.88, 2.47); p<0.05; I 2 =97.4%]. All the outcomes had a high level of inter-study heterogeneity, but sensitivity analysis showed that no study was sensitive enough to change these results. Publication bias was present only in the analysis of sperm concentration and progressive motility. No significant difference was found in semen volume [SMD 0.13 ml (95% CI: -0.24, 0.87); p=0.27; I 2 =89.7%].
dc.identifier.citationAgarwal, A., Cannarella, R., Saleh, R., Boitrelle, F., Hamoda, T. A.-M., Gül, M. ... Shah, R. (2022). Effect of varicocele repair on conventional sperm parameters in infertile patients with clinical varicocele: A systematic review and metaanalysis. Fertility and Sterility içinde (E310-E310. ss.).
dc.identifier.endpageE310
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue4
dc.identifier.startpageE310
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10632
dc.identifier.volume118
dc.identifier.wos000891804601027en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.institutionauthorÇalık, Gökhan
dc.language.isoen
dc.publisherElsevier Science Inc.
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectInfertile Patients
dc.subjectConventional Sperm Parameters
dc.subjectVaricocele Repair
dc.titleEffect of varicocele repair on conventional sperm parameters in infertile patients with clinical varicocele: A systematic review and metaanalysis.
dc.typeConference Object

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Calik-Gokhan-2022.pdf
Boyut:
141.49 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Bildiri Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu