The antifungal activity and cytotoxicity of silver containing denture base material

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dc.authorid0000-0002-0060-2859
dc.contributor.authorKurt, Ayşegül
dc.contributor.authorErköse Genç, Gonca
dc.contributor.authorUzun, Meltem
dc.contributor.authorEmrence, Zeliha
dc.contributor.authorÜstek, Duran
dc.contributor.authorIşık Özkol, Gülbahar
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:04Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:04Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000396164700005
dc.descriptionPubMed ID: 28256482
dc.description.abstractObjective: Denture base materials are susceptible to fungal adhesion, which is an important etiological issue in the pathogenesis of denture stomatitis. The purpose of this in vitro study was to evaluate the antifungal activity and cytotoxicity of denture base material containing silver microparticles. Materials and Methods: The polymethyl methacrylate (PMMA) denture base material was used, and silver microparticles were added to the polymer powder in different concentrations by volume (0%, 0.25%, 0.5%, and 1%). Their antifungal activity against Candida albicans was assessed in terms of colony-forming units. PMMA disc specimens containing silver microparticles were eluted with culture medium for 1, 2, and 5 days. The cytotoxicity of the eluates to cultured L929 mouse fibroblast cells was evaluated using a real-time cell analysis (RTCA) system and the 3-[ 4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. Results: The antifungal effect against C. albicans increased with the percentage of silver microparticles (P < 0.05). For both tests, both RTCA and the MTT assay, no time-or silver-dependent cytotoxicity of PMMA denture base material containing silver microparticles was observed. Conclusions: PMMA denture base material containing silver microparticles have antifungal activity and no cytotoxic effect.
dc.description.sponsorshipResearch Support Unit of Istanbul University [19648]en_US
dc.description.sponsorshipThis study was supported by the Research Support Unit of Istanbul University (project no. 19648). The authors thank Association Prof. Ugur Aksu for performing statistical analyses of the results.en_US
dc.identifier.citationKurt, A., Erköse Genç, G., Uzun, M., Emrence, Z., Üstek, D. ve Işık Özkol, G. (2017). The antifungal activity and cytotoxicity of silver containing denture base material. Nigerian Journal of Clinical Practice, 20(3), 290-295. https://dx.doi.org/10.4103/1119-3077.181362
dc.identifier.doi10.4103/1119-3077.181362
dc.identifier.endpage295
dc.identifier.issn1119-3077
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage290
dc.identifier.urihttps://dx.doi.org/10.4103/1119-3077.181362
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3540
dc.identifier.volume20
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedknow Publications & Media Pvt Ltd.
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/*
dc.subjectCandida Albicans
dc.subjectCytotoxicity
dc.subjectDenture Base
dc.subjectSilver Microparticles
dc.titleThe antifungal activity and cytotoxicity of silver containing denture base material
dc.typeArticle

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