Radical nephroureterectomy for UTUC conferred survival benefits irrespective of age and comorbidities

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dc.authorid0000-0002-6308-1763
dc.contributor.authorTeoh, Jeremy Yuen-Chun
dc.contributor.authorNg, Chi-Fai
dc.contributor.authorEto, Masatoshi
dc.contributor.authorChiruvella, Mallikarjuna
dc.contributor.authorCapitanio, Umberto
dc.contributor.authorEsen, Tarık
dc.contributor.authorZeng, Guohua
dc.contributor.authorLechevallier, Eric
dc.contributor.authorAndonian, Sero
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.date.accessioned2022-12-01T10:08:49Z
dc.date.available2022-12-01T10:08:49Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose We investigated the effects of age, American Society of Anesthesiologists Physical Status Classification (ASA) grading and Charlson Comorbidity Index (CCI) on the survival outcomes of upper tract urothelial carcinoma (UTUC). Methods The CROES-UTUC registry was an international, multicenter study on patients with UTUC. Primary outcomes were overall survival (OS) and disease-free survival (DFS). Kaplan-Meier and multivariate Cox regression analyses were performed by stratifying patients according to their age (<= 70 and > 70 years old) and ASA grade (I-II and III-V)/CCI (0-1 and >= 2). Results A total of 2352 patients were included in this study. Patients aged <= 70 years with ASA grading of I-II (p = 0.002), and patients aged <= 70 years with a CCI of 0-1 (p = 0.002) had the best OS. Upon multivariate analysis, both in patients aged <= 70 and > 70 years, ASA grading and CCI were not significantly associated with OS. Patients aged <= 70 years with ASA grading of III-IV (p = 0.024) had the best DFS. When stratified according to age and CCI, no significant difference in DFS was noted. Upon multivariate analysis, radical nephroureterectomy (RNU) was significantly associated with better DFS in patients aged <= 70 and > 70 years; CCI of >= 3 was significantly associated with worse DFS in patients <= 70 years; ASA grading was not associated with DFS in patients aged <= 70 and > 70 years. Conclusions A high ASA grading and CCI should not be considered contraindications for RNU. RNU should be considered even in elderly patients when it is deemed feasible and achievable after a geriatric assessment.
dc.description.sponsorshipSTORZ to the Clinical Research Office of the Endourology Society (CROES)en_US
dc.identifier.citationTeoh, J. Y.-C., Ng, C.-F., Eto, M., Chiruvella, M., Capitanio, U., Esen, T. ... de la Rosette, J. J. M. C. H. (2022). Radical nephroureterectomy for UTUC conferred survival benefits irrespective of age and comorbidities. World Journal of Urology, 40(11), 2657-2665. https://doi.org/10.1007/s00345-022-04152-7
dc.identifier.doi10.1007/s00345-022-04152-7
dc.identifier.endpage2665
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.issue11
dc.identifier.pmid36125506
dc.identifier.scopus2-s2.0-85138338645
dc.identifier.scopusqualityQ1
dc.identifier.startpage2657
dc.identifier.urihttps://doi.org/10.1007/s00345-022-04152-7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10056
dc.identifier.volume40
dc.identifier.wos000855634200002en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofWorld Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAge
dc.subjectASA
dc.subjectCharlson Comorbidity Index
dc.subjectNephroureterectomy
dc.subjectUrothelial Carcinoma
dc.subjectUTUC
dc.titleRadical nephroureterectomy for UTUC conferred survival benefits irrespective of age and comorbidities
dc.typeArticle

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